A genetically determined molecular switch modulates the anti-inflammatory potential of human IgA

Fc receptor-driven immune system activity typically reflects a balance of activating and inhibitory mechanisms, mediated by the immunoreceptor tyrosine-based activation motif (ITAM) or inhibition motif (ITIM) in the ligand-binding alpha chain (FcγRIIa – c) or the canonical ITAM in the associated Fc...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 16; p. 1641351
Main Authors:	Gibson, Andrew W., Wu, Jianming, Hendrickson, R. Curtis, Ptacek, Travis, Mobley, James, Edberg, Jeffrey C., Kimberly, Robert P.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media SA 2025 Frontiers Media S.A
Subjects:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Agammaglobulinaemia Tyrosine Kinase - metabolism Alleles Antigens, CD - genetics Antigens, CD - immunology Antigens, CD - metabolism Bruton's tyrosine kinase CD89 CD89 antigen Cloning Cytokines Fc receptors FCAR Humans Immune system Immunoglobulin A Immunoglobulin A - genetics Immunoglobulin A - immunology Immunoglobulin A - metabolism Immunoreceptor tyrosine-based activation motif Immunoreceptor tyrosine-based inhibition motif Inflammation inhibition Kinases Neutrophils Phosphorylation Polymorphism Proteins Receptors, Fc - genetics Receptors, Fc - immunology Receptors, Fc - metabolism Receptors, IgG - genetics Serine SH3BP5 (Sab) Signal Transduction St Louis Missouri Grand Island United States > US SH3BP5 (Sab) inhibition signal transduction CD89 FCAR alleles
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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