Assessment of Plasma-Endogenous Opioid Neuropeptide Levels and Psychometric Properties of Non-Suicidal Self-Injury in Adolescents

Non-suicidal self-injury (NSSI) is one of the most common mental health problems and growing public-health issues, coupled with a significant population-level burden among adolescents in both developed and developing countries. We aimed to assess the role of endogenous opioid system-emotion regulati...

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Vydáno v:Archives of suicide research Ročník 27; číslo 2; s. 749 - 768
Hlavní autoři: Cakin Memik, Nursu, Hunc, Fatih, Kalayci, Seyma, Demir, Necmettin, Senturk, Elif, Yildiz Gundogdu, Ozlem, Ozlen Dillioglugil, Meltem
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Routledge 03.04.2023
Taylor & Francis Ltd
Témata:
Adolescent
Adolescents
Analgesics, Opioid
beta-endorphin
brief symptom inventory
Child
Developing countries
Emotional Regulation
Emotions
Endogenous
Health problems
Humans
Injuries
inventory of statements about self-injury
LDCs
Measurement
Measures
Mental depression
Mental disorders
Mental health
Narcotics
Neuropeptides
non-suicidal self-injury
Opioids
Plasma
Plasma levels
Property
Psychometrics
Public health
Quantitative psychology
Research subjects
Self destructive behavior
Self evaluation
Self injury
Self-Injurious Behavior - psychology
Sociodemographics
Suicidal behavior
Suicide
Teenagers
beta-endorphin
inventory of statements about self-injury
Adolescents
non-suicidal self-injury
brief symptom inventory
ISSN:1381-1118, 1543-6136, 1543-6136
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Shrnutí:Non-suicidal self-injury (NSSI) is one of the most common mental health problems and growing public-health issues, coupled with a significant population-level burden among adolescents in both developed and developing countries. We aimed to assess the role of endogenous opioid system-emotion regulation circuitry in NSSI through measurement of plasma beta-endorphin (β-EP), met-enkephalin (MENK) levels, and determination of psychometric features of Turkish adolescent subjects. In this research, we measured plasma β-EP and MENK levels of 49 adolescents with NSSI and 39 control subjects without NSSI between the ages of 12-18 years. All adolescent subjects were observed in the outpatient clinic, and their clinical and sociodemographic characteristics were examined. All subjects were assessed using the Brief Symptom Inventory (BSI) and Inventory of Statements About Self Injury (ISAS). Plasma β-EP levels were statistically lower in adolescents with NSSI than control group, whereas there was no statistically significant difference in MENK levels. β-EP levels showed a negative correlation with depression severity. The data obtained from BSI and ISAS were not found to be associated with both β-EP and MENK levels, while subscale scores exhibited versatile correlations. Our findings supported the salient role of β-EP in NSSI behavior. Also, decreased plasma β-EP could be assessed as a reliable indicator for NSSI. However, it is possible that measurement of basal plasma levels of neuropeptides might also bring many confounders and could cause bias. Therefore, repeated measurements of plasma-endogenous opioid neuropeptides in a time-dependent manner-concomitant to engage of NSSI behavior-might give more reliable results.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1381-1118
1543-6136
1543-6136
DOI:10.1080/13811118.2022.2066494