Thrombophilia and outcome in severe infection and sepsis

Thrombophilia is associated with a prohemostatic state and consequently with an increased tendency to develop thrombosis. In severe infection and sepsis, activation of coagulation frequently occurs, which contributes to the development of multiple organ dysfunction. Hypothetically, patients with thr...

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Vydáno v:Seminars in thrombosis and hemostasis Ročník 33; číslo 6; s. 604
Hlavní autoři: Hofstra, Jorrit-Jan, Schouten, Marcel, Levi, Marcel
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.09.2007
Témata:
Factor V - genetics
Fibrinolysis - genetics
Genetic Variation
Humans
Infection - blood
Infection - complications
Infection - therapy
Polymorphism, Genetic
Protein C - genetics
Sepsis - blood
Sepsis - complications
Sepsis - therapy
Thrombophilia - blood
Thrombophilia - complications
Thrombophilia - genetics
Treatment Outcome
ISSN:0094-6176
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Shrnutí:Thrombophilia is associated with a prohemostatic state and consequently with an increased tendency to develop thrombosis. In severe infection and sepsis, activation of coagulation frequently occurs, which contributes to the development of multiple organ dysfunction. Hypothetically, patients with thrombophilia may suffer from more severe coagulopathy in the presence of severe infection or sepsis, which may result in a more serious clinical course and an unfavorable outcome. This article reviews experimental and clinical evidence regarding such a relationship, with a particular focus on deficiencies of natural anticoagulant proteins (protein C and antithrombin), the factor V Leiden mutation, and genetic variation in the fibrinolytic system.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:0094-6176
DOI:10.1055/s-2007-985757