Polychlorinated Biphenyl and Organochlorine Pesticide Concentrations in Maternal Mid-Pregnancy Serum Samples: Association with Autism Spectrum Disorder and Intellectual Disability

Polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) are neurodevelopmental toxicants, but few studies have examined associations with autism spectrum disorder (ASD). We aimed to determine whether prenatal exposure to PCBs and OCPs influences offspring risk of ASD and intellectual d...

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Vydáno v:Environmental health perspectives Ročník 125; číslo 3; s. 474 - 480
Hlavní autoři: Lyall, Kristen, Croen, Lisa. A., Sjödin, Andreas, Yoshida, Cathleen K., Zerbo, Ousseny, Kharrazi, Martin, Windham, Gayle C.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States National Institute of Environmental Health Sciences 01.03.2017
Témata:
Adult
Archives & records
Autism
Autism Spectrum Disorder - epidemiology
Birth certificates
Blood
California
Case-Control Studies
Child
Children & youth
Classification
Cognitive ability
Comorbidity
DDE
Developmental disabilities
Environmental Pollutants - blood
Female
Human subjects
Humans
Hydrocarbons, Chlorinated - blood
Immune system
Intellectual disabilities
Intellectual Disability - epidemiology
Logistic Models
Male
Maternal Exposure - statistics & numerical data
Medical laboratories
Medical screening
Mental disorders
Nitrous oxide
Odds Ratio
Offspring
Organic compounds
Organochlorine compounds
Organochlorine pesticides
PCB
Pesticide toxicity
Pesticides
Pesticides - blood
Polychlorinated biphenyls
Polychlorinated Biphenyls - blood
Population
Pregnancy
Studies
Toxicants
United States > US
ISSN:0091-6765, 1552-9924, 1552-9924
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Shrnutí:Polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) are neurodevelopmental toxicants, but few studies have examined associations with autism spectrum disorder (ASD). We aimed to determine whether prenatal exposure to PCBs and OCPs influences offspring risk of ASD and intellectual disability without autism (ID). We conducted a population-based case-control study among Southern California births, including children with ASD ( = 545) meeting (DSM-IV-TR) criteria and ID ( = 181), as well as general population (GP) controls ( = 418). Concentrations of 11 PCB congeners and 2 OCPs measured in banked second-trimester serum samples were compared between the diagnostic groups. Logistic regression was used to calculate crude and adjusted odds ratios (AOR) for associations with ASD, and separately for ID, compared with GP controls, by quartiles of analyte concentrations in primary analyses. Geometric mean levels of several PCB congeners were higher in the ASD group than in the ID and GP groups. ASD risk was elevated for a number of PCB congeners, particularly for the highest vs. lowest quartile of PCB138/158 (AOR = 1.79; 95% CI: 1.10, 2.71) and PCB153 (AOR = 1.82; 95% CI: 1.10, 3.02), and for highest deciles of other congeners in secondary analyses. PCB138/158 was also associated with increased ID (AOR = 2.41; 95% CI: 1.18, 4.91), though no trend was suggested. OCPs were not associated with increased risk of ASD in primary analyses, whereas nonmonotonic increases in risk of ID were found with ´-DDE. Our results suggest higher levels of some organochlorine compounds during pregnancy are associated with ASD and ID. Citation: Lyall K, Croen LA, Sjödin A, Yoshida CK, Zerbo O, Kharrazi M, Windham GC. 2017. Polychlorinated biphenyl and organochlorine pesticide concentrations in maternal mid-pregnancy serum samples: association with autism spectrum disorder and intellectual disability. Environ Health Perspect 125:474-480; http://dx.doi.org/10.1289/EHP277.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Current address for K.L.: AJ Drexel Autism Institute, Philadelphia, PA 19104 USA.
ISSN:0091-6765
1552-9924
1552-9924
DOI:10.1289/EHP277