Preliminary evaluation of plasticizer and BPA in Tunisian cosmetics and investigation of hazards on human skin cells

In this study, 18 plasticizer (phthalates, adipates, sebacates, and others) and BPA residues in some cosmetic samples collected from Tunisian market are evaluated by micro-matrix solid-phase dispersion combined with GC-MS. In parallel, the impact of these molecules and the cosmetics in the human epi...

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Bibliographic Details
Published in:International journal of environmental health research Vol. 28; no. 5; pp. 491 - 501
Main Authors: Beltifa, Asma, Belaid, Afifa, Lo Turco, Vincenzo, Machreki, Monia, Ben Mansour, Hedi, Di Bella, Giuseppa
Format: Journal Article
Language:English
Published: England Taylor & Francis 01.10.2018
Taylor & Francis LLC
Subjects:
Animals
Benzhydryl Compounds - analysis
Benzhydryl Compounds - toxicity
Biotechnology
Calibration
Cell Line
Cell lines
consumer health
Cosmetic products
Cosmetics
Cosmetics - analysis
Cosmetics industry
Cytotoxicity
cytoxicity
Epithelial cells
Epithelial Cells - drug effects
Gas Chromatography-Mass Spectrometry - methods
GCMS/MS
Hazards
Humans
Limit of Detection
Mice
Phenols - analysis
Phenols - toxicity
Phthalates
Phthalic Acids - analysis
Plasticizers - analysis
Plasticizers - toxicity
plasticizers and bisphenol A
Product safety
Reproducibility of Results
Skin
Skin - cytology
Skin - drug effects
Toxicity Tests
Tunisia
plasticizers and bisphenol A
GCMS/MS
cytoxicity
consumer health
Cosmetic products
ISSN:0960-3123, 1369-1619, 1369-1619
Online Access:Get full text
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Summary:In this study, 18 plasticizer (phthalates, adipates, sebacates, and others) and BPA residues in some cosmetic samples collected from Tunisian market are evaluated by micro-matrix solid-phase dispersion combined with GC-MS. In parallel, the impact of these molecules and the cosmetics in the human epithelial cell lines is investigated. The cytotoxic activity of cosmetic extracts is evaluated in vitro against B16 and Hep-2 human skin cell lines using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide assay. This study shows that the tested cosmetic products could constitute a hazard to the consumer health and wellness and that strict safety analysis on cosmetic products needs to be carried out before they are marketed.
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ISSN:0960-3123
1369-1619
1369-1619
DOI:10.1080/09603123.2018.1489528