Reassortment and migration analysis of Crimean-Congo haemorrhagic fever virus

Crimean-Congo haemorrhagic fever virus (CCHFV) is a tick-borne virus with high pathogenicity to humans. CCHFV contains a three-segment [small (S), medium (M) and large (L)] genome and is prone to reassortment. Investigation of identified reassortment events can yield insight into the evolutionary hi...

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Bibliographic Details
Published in:Journal of general virology Vol. 94; no. Pt 11; p. 2536
Main Authors: Zhou, Zhaorui, Deng, Fei, Han, Na, Wang, Hualin, Sun, Surong, Zhang, Yujiang, Hu, Zhihong, Rayner, Simon
Format: Journal Article
Language:English
Published: England 01.11.2013
Subjects:
Animal Migration
Animals
Birds - parasitology
Birds - physiology
Computational Biology - methods
Genome, Viral - genetics
Hemorrhagic Fever Virus, Crimean-Congo - classification
Hemorrhagic Fever Virus, Crimean-Congo - genetics
Hemorrhagic Fever Virus, Crimean-Congo - isolation & purification
Hemorrhagic Fever, Crimean - transmission
Hemorrhagic Fever, Crimean - virology
Humans
Phylogeny
Reassortant Viruses - genetics
Recombination, Genetic - genetics
RNA, Viral - genetics
Tick Infestations - parasitology
Tick Infestations - transmission
Tick-Borne Diseases - transmission
Tick-Borne Diseases - virology
Ticks - virology
ISSN:1465-2099, 1465-2099
Online Access:Get more information
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Summary:Crimean-Congo haemorrhagic fever virus (CCHFV) is a tick-borne virus with high pathogenicity to humans. CCHFV contains a three-segment [small (S), medium (M) and large (L)] genome and is prone to reassortment. Investigation of identified reassortment events can yield insight into the evolutionary history of the virus, while migration events reflect its geographical dissemination. While many studies have already considered these issues, they have investigated small numbers of isolates and lack statistical support for their findings. Here, we consider a larger set of 30 full genomes to investigate reassortment using recombination methods, as well as two sets of partial S segments comprising 393 isolates, reflecting a broader geographical range, to investigate migration events. Phylogenetic analysis revealed that the S segment showed strong geographical subdivision, but this was less apparent in the M and L segments. A total of 16 reassortment events with 22 isolates were identified with strong statistical support. Migration analysis on the partial S segments identified both long- and short-range migration events that spanned the entire geographical region in which the CCHFV has been isolated, reflecting the complex processes associated with the dissemination of the virus.
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ISSN:1465-2099
1465-2099
DOI:10.1099/vir.0.056374-0