Visualization of hepatic uptake transporter function in healthy subjects by using gadoxetic acid-enhanced MR imaging

To determine if genetic polymorphisms of liver-specific human organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 influence cellular uptake of gadoxetic acid in vitro and if functionally relevant polymorphisms are confounders for liver enhancement by gadoxetic acid in healthy subjects. Thi...

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Bibliographic Details
Published in:	Radiology Vol. 264; no. 3; p. 741
Main Authors:	Nassif, Ali, Jia, Jia, Keiser, Markus, Oswald, Stefan, Modess, Christiane, Nagel, Stefan, Weitschies, Werner, Hosten, Norbert, Siegmund, Werner, Kühn, Jens-Peter
Format:	Journal Article
Language:	English
Published:	United States 01.09.2012
Subjects:	Alleles Analysis of Variance Area Under Curve Blotting, Western Chromatography, Liquid Contrast Media - pharmacokinetics Gadolinium DTPA - pharmacokinetics Genotype Humans Liver - cytology Liver - metabolism Magnetic Resonance Imaging - methods Organic Anion Transporters - genetics Organic Anion Transporters, Sodium-Independent - genetics Pharmacogenetics Polymorphism, Genetic Solute Carrier Organic Anion Transporter Family Member 1b1 Solute Carrier Organic Anion Transporter Family Member 1B3 Tandem Mass Spectrometry Transfection
ISSN:	1527-1315, 1527-1315
Online Access:	Get more information
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