Visualization of hepatic uptake transporter function in healthy subjects by using gadoxetic acid-enhanced MR imaging

To determine if genetic polymorphisms of liver-specific human organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 influence cellular uptake of gadoxetic acid in vitro and if functionally relevant polymorphisms are confounders for liver enhancement by gadoxetic acid in healthy subjects. Thi...

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Veröffentlicht in:	Radiology Jg. 264; H. 3; S. 741
Hauptverfasser:	Nassif, Ali, Jia, Jia, Keiser, Markus, Oswald, Stefan, Modess, Christiane, Nagel, Stefan, Weitschies, Werner, Hosten, Norbert, Siegmund, Werner, Kühn, Jens-Peter
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.09.2012
Schlagworte:	Alleles Analysis of Variance Area Under Curve Blotting, Western Chromatography, Liquid Contrast Media - pharmacokinetics Gadolinium DTPA - pharmacokinetics Genotype Humans Liver - cytology Liver - metabolism Magnetic Resonance Imaging - methods Organic Anion Transporters - genetics Organic Anion Transporters, Sodium-Independent - genetics Pharmacogenetics Polymorphism, Genetic Solute Carrier Organic Anion Transporter Family Member 1b1 Solute Carrier Organic Anion Transporter Family Member 1B3 Tandem Mass Spectrometry Transfection
ISSN:	1527-1315, 1527-1315
Online-Zugang:	Weitere Angaben
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