Inorganic cadmium- and arsenite-induced malignant transformation of human bladder urothelial cells

Arsenic and cadmium (Cd(+2)) are human carcinogens, and epidemiological studies have implicated both pollutants in the development of urinary bladder cancer. Despite this epidemiological base, it is unknown if either Cd(+2) or arsenite (As(+3)) can directly cause the malignant transformation of huma...

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Vydáno v:	Toxicological sciences Ročník 79; číslo 1; s. 56
Hlavní autoři:	Sens, Donald A, Park, Seongmi, Gurel, Volkan, Sens, Mary Ann, Garrett, Scott H, Somji, Seema
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.05.2004
Témata:	Agar Animals Arsenicals - adverse effects Cadmium Compounds - adverse effects Cell Culture Techniques - methods Cell Division - drug effects Cell Line Cell Transformation, Neoplastic - drug effects Cell Transformation, Neoplastic - pathology Cell Transformation, Neoplastic - ultrastructure Dose-Response Relationship, Drug Humans Mice Mice, Nude - genetics Neoplasm Transplantation - methods Neoplasm Transplantation - pathology Neoplasms, Experimental - chemically induced Neoplasms, Experimental - pathology Neoplasms, Experimental - ultrastructure Time Factors Urinary Bladder - pathology Urothelium - drug effects Urothelium - pathology
ISSN:	1096-6080
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