Application of Graph Neural Networks to Model Stem Cell Donor–Recipient Compatibility in the Detection and Classification of Leukemia
Stem cell transplants are a common treatment for leukemia, and close donor–recipient matching improves their success. Machine learning models like support vector machine (SVM), convolutional neural networks (CNNs), and recurrent neural networks (RNNs) can have difficulty handling the complexity of g...
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| Vydané v: | Applied sciences Ročník 15; číslo 21; s. 11500 |
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| Jazyk: | English |
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MDPI AG
01.11.2025
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| ISSN: | 2076-3417, 2076-3417 |
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| Abstract | Stem cell transplants are a common treatment for leukemia, and close donor–recipient matching improves their success. Machine learning models like support vector machine (SVM), convolutional neural networks (CNNs), and recurrent neural networks (RNNs) can have difficulty handling the complexity of genomic and immune data, which then lowers the accuracy of clinical predictions. This study looks at using graph neural networks (GNNs) in a different way. This method combines data such as single-nucleotide polymorphisms (SNPs), human leukocyte antigen (HLA) typing, and clinical details to create a graph that shows the relationship between donor and recipient pairs. The framework uses graph attention networks (GATs) to focus on key compatibility traits and Dynamic GNNs (DGNNs) to monitor changes in the immune system and the disease’s progression. With data from the 1000 Genomes Project, the model correctly identified matches with 97.68% to 99.74% accuracy and classified them with 98.76% to 99.4% accuracy, outperforming standard machine learning models. The model uses SNP similarity and HLA mismatches to assess compatibility, which enhances its match prediction and compatibility explanation capabilities. The results suggest that GNNs offer a helpful and understandable way to model donor–recipient matching, potentially assisting in early leukemia detection and personalized stem cell transplant plans. |
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| AbstractList | Stem cell transplants are a common treatment for leukemia, and close donor–recipient matching improves their success. Machine learning models like support vector machine (SVM), convolutional neural networks (CNNs), and recurrent neural networks (RNNs) can have difficulty handling the complexity of genomic and immune data, which then lowers the accuracy of clinical predictions. This study looks at using graph neural networks (GNNs) in a different way. This method combines data such as single-nucleotide polymorphisms (SNPs), human leukocyte antigen (HLA) typing, and clinical details to create a graph that shows the relationship between donor and recipient pairs. The framework uses graph attention networks (GATs) to focus on key compatibility traits and Dynamic GNNs (DGNNs) to monitor changes in the immune system and the disease’s progression. With data from the 1000 Genomes Project, the model correctly identified matches with 97.68% to 99.74% accuracy and classified them with 98.76% to 99.4% accuracy, outperforming standard machine learning models. The model uses SNP similarity and HLA mismatches to assess compatibility, which enhances its match prediction and compatibility explanation capabilities. The results suggest that GNNs offer a helpful and understandable way to model donor–recipient matching, potentially assisting in early leukemia detection and personalized stem cell transplant plans. |
| Audience | Academic |
| Author | Eltanashi, Saeeda Meftah Salem Kurnaz Türkben, Ayça |
| Author_xml | – sequence: 1 givenname: Saeeda Meftah Salem surname: Eltanashi fullname: Eltanashi, Saeeda Meftah Salem – sequence: 2 givenname: Ayça surname: Kurnaz Türkben fullname: Kurnaz Türkben, Ayça |
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| Cites_doi | 10.1182/hematology.2019000357 10.1016/S2666-6367(21)00273-6 10.1038/s41375-021-01253-x 10.1080/16078454.2021.1966224 10.1182/blood.2019000904 10.1016/j.stemcr.2020.07.008 10.1080/10428194.2023.2281269 10.1038/leu.2015.59 10.1111/bjh.13352 10.1111/petr.13672 10.1038/s41409-020-01201-w 10.1038/s41375-018-0218-6 10.1007/978-981-19-5802-1_51 10.1007/s00521-023-08678-8 10.1182/bloodadvances.2019000394 10.18632/oncotarget.20878 10.18632/oncotarget.28686 10.1002/ajh.25810 10.1200/JCO.2008.17.6065 10.1182/blood-2018-10-882944 10.3324/haematol.2023.283224 10.1182/blood-2023-189049 10.1016/j.bbmt.2011.11.007 10.1111/bjh.12639 10.1182/blood-2011-03-338707 10.1016/j.bspc.2024.106459 10.1080/16078454.2025.2532915 10.1182/blood-2017-01-761320 10.1016/j.xcrm.2025.101989 10.1002/pbc.27481 10.1038/s41375-019-0548-z 10.1016/j.bbmt.2010.10.010 10.1016/S1470-2045(17)30417-5 10.1111/bjh.12847 10.1002/pbc.24922 10.1016/j.leukres.2024.107546 10.1109/ICAIBD57115.2023.10206402 10.1182/blood.V130.Suppl_1.844.844 10.1002/hon.2187 10.1182/hematology.2020000134 10.30871/jaic.v9i2.8941 10.1016/S1470-2045(14)70243-8 10.1182/blood.V122.21.1995.1995 10.1182/blood-2015-02-629527 10.1038/s41375-021-01282-6 |
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| References | Bader (ref_29) 2009; 27 DeZern (ref_11) 2020; 4 Vogiatzi (ref_33) 2019; 134 Hildebrandt (ref_6) 2015; 1 Locatelli (ref_25) 2017; 8 Oshrine (ref_21) 2020; 24 Zhang (ref_8) 2021; 26 Strocchio (ref_16) 2015; 169 Cooper (ref_40) 2017; 130 Baronciani (ref_18) 2015; 34 Verstraete (ref_13) 2023; 65 Vora (ref_28) 2014; 15 Parmar (ref_3) 2024; 144 Versluys (ref_24) 2021; 56 Engel (ref_9) 2018; 33 Georgiadis (ref_39) 2021; 35 Bader (ref_41) 2013; 122 Mamonkin (ref_37) 2015; 126 Kussman (ref_23) 2018; 66 Febriyanti (ref_44) 2025; 9 Buttigieg (ref_10) 2025; 6 Lamble (ref_35) 2020; 2020 Wiseman (ref_7) 2011; 17 Srinivasan (ref_36) 2017; 130 Dietz (ref_5) 2014; 166 Lamble (ref_32) 2019; 2019 Talaat (ref_20) 2023; 35 Satwani (ref_19) 2012; 18 Kato (ref_22) 2013; 61 Windreich (ref_15) 2021; 27 Baroni (ref_38) 2019; 133 Uzay (ref_17) 2023; 142 (ref_1) 2025; 16 ref_46 ref_45 Giardino (ref_14) 2020; 95 Burns (ref_12) 2020; 15 Daver (ref_31) 2021; 35 Wang (ref_43) 2025; 30 Balduzzi (ref_42) 2014; 164 Ofran (ref_34) 2019; 34 ref_2 Schmid (ref_4) 2024; 109 Eckert (ref_30) 2015; 29 Locatelli (ref_26) 2017; 18 Schrappe (ref_27) 2011; 118 |
| References_xml | – volume: 2019 start-page: 218 year: 2019 ident: ref_32 article-title: Opportunities for immunotherapy in childhood acute myeloid leukemia publication-title: Hematology doi: 10.1182/hematology.2019000357 – volume: 27 start-page: S221 year: 2021 ident: ref_15 article-title: A Phase II Study of Myeloablative and Reduced-Intensity Conditioning Regimens for Children and Adolescents with Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Allogeneic Hematopoietic Stem Cell Transplantation publication-title: Transplant. Cell Ther. doi: 10.1016/S2666-6367(21)00273-6 – volume: 35 start-page: 1843 year: 2021 ident: ref_31 article-title: T-cell-based immunotherapy of acute myeloid leukemia: Current concepts and future developments publication-title: Leukemia doi: 10.1038/s41375-021-01253-x – volume: 26 start-page: 648 year: 2021 ident: ref_8 article-title: Donor cell leukemia/myelodysplastic syndrome after allogeneic stem cell transplantation: A rare phenomenon with more challenges for hematologists publication-title: Hematology doi: 10.1080/16078454.2021.1966224 – volume: 134 start-page: 713 year: 2019 ident: ref_33 article-title: Daratumumab eradicates minimal residual disease in a preclinical model of pediatric T-cell acute lymphoblastic leukemia publication-title: Blood doi: 10.1182/blood.2019000904 – volume: 15 start-page: 279 year: 2020 ident: ref_12 article-title: Clonal Hematopoiesis of Indeterminate Potential as a Novel Risk Factor for Donor-Derived Leukemia publication-title: Stem Cell Rep. doi: 10.1016/j.stemcr.2020.07.008 – volume: 65 start-page: 283 year: 2023 ident: ref_13 article-title: Comparison of two reduced intensity conditioning regimens: Flu-Bu2 versus RIC-TBF in allogeneic hematopoietic stem cell transplantation publication-title: Leuk. Lymphoma doi: 10.1080/10428194.2023.2281269 – volume: 29 start-page: 1648 year: 2015 ident: ref_30 article-title: Monitoring minimal residual disease in children with high-risk relapses of acute lymphoblastic leukemia: Prognostic relevance of early and late assessment publication-title: Leukemia doi: 10.1038/leu.2015.59 – volume: 169 start-page: 726 year: 2015 ident: ref_16 article-title: Treosulfan-based conditioning regimen for allogeneic haematopoietic stem cell transplantation in children with sickle cell disease publication-title: Br. J. Haematol. doi: 10.1111/bjh.13352 – volume: 24 start-page: e13672 year: 2020 ident: ref_21 article-title: Comparison of melphalan- And busulfan-based myeloablative conditioning in children undergoing allogeneic transplantation for acute myeloid leukemia or myelodysplasia publication-title: Pediatr. Transplant. doi: 10.1111/petr.13672 – volume: 56 start-page: 1426 year: 2021 ident: ref_24 article-title: Hematopoietic cell transplant in pediatric acute myeloid leukemia after similar upfront therapy; a comparison of conditioning regimens publication-title: Bone Marrow Transplant. doi: 10.1038/s41409-020-01201-w – volume: 33 start-page: 508 year: 2018 ident: ref_9 article-title: European experience and risk factor analysis of donor cell-derived leukaemias/MDS following haematopoietic cell transplantation publication-title: Leukemia doi: 10.1038/s41375-018-0218-6 – ident: ref_2 doi: 10.1007/978-981-19-5802-1_51 – volume: 35 start-page: 18059 year: 2023 ident: ref_20 article-title: A2M-LEUK: Attention-augmented algorithm for blood cancer detection in children publication-title: Neural Comput. Appl. doi: 10.1007/s00521-023-08678-8 – volume: 4 start-page: 784 year: 2020 ident: ref_11 article-title: Stem cell donors should be screened for CHIP publication-title: Blood Adv. doi: 10.1182/bloodadvances.2019000394 – volume: 8 start-page: 96460 year: 2017 ident: ref_25 article-title: Rabbit anti-human T-lymphocyte globulin and hematopoietic transplantation publication-title: Oncotarget doi: 10.18632/oncotarget.20878 – volume: 16 start-page: 44 year: 2025 ident: ref_1 article-title: A case report of donor cell-derived hematologic neoplasms 9 years after allogeneic hematopoietic cell transplantation publication-title: Oncotarget doi: 10.18632/oncotarget.28686 – volume: 95 start-page: 809 year: 2020 ident: ref_14 article-title: Outcome of patients with Fanconi anemia developing myelodysplasia and acute leukemia who received allogeneic hematopoietic stem cell transplantation: A retrospective analysis on behalf of EBMT group publication-title: Am. J. Hematol. doi: 10.1002/ajh.25810 – volume: 27 start-page: 377 year: 2009 ident: ref_29 article-title: Prognostic Value of Minimal Residual Disease Quantification Before Allogeneic Stem-Cell Transplantation in Relapsed Childhood Acute Lymphoblastic Leukemia: The ALL-REZ BFM Study Group publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2008.17.6065 – volume: 133 start-page: 2291 year: 2019 ident: ref_38 article-title: Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia publication-title: Blood doi: 10.1182/blood-2018-10-882944 – volume: 109 start-page: 617 year: 2024 ident: ref_4 article-title: Efficacy and feasibility of Pharmacoscopy-guided treatment for acute myeloid leukemia patients that exhausted all registered therapeutic options publication-title: Hematologica doi: 10.3324/haematol.2023.283224 – volume: 142 start-page: 6958 year: 2023 ident: ref_17 article-title: Outcomes of Treosulfan Vs. Busulfan Based Conditioning Regimens in Adult Patients Undergoing Allogeneic HSCT: Real Life Data from a Single Center publication-title: Blood doi: 10.1182/blood-2023-189049 – volume: 18 start-page: 324 year: 2012 ident: ref_19 article-title: A Phase I Study of Gemtuzumab Ozogamicin (GO) in Combination with Busulfan and Cyclophosphamide (Bu/Cy) and Allogeneic Stem Cell Transplantation in Children with Poor-Risk CD33+ AML: A New Targeted Immunochemotherapy Myeloablative Conditioning (MAC) Regimen publication-title: Biol. Blood Marrow Transplant. doi: 10.1016/j.bbmt.2011.11.007 – volume: 164 start-page: 396 year: 2014 ident: ref_42 article-title: Minimal residual disease before and after transplantation for childhood acute lymphoblastic leukaemia: Is there any room for intervention? publication-title: Br. J. Haematol. doi: 10.1111/bjh.12639 – volume: 118 start-page: 2077 year: 2011 ident: ref_27 article-title: Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL: Results of the AIEOP-BFM-ALL 2000 study publication-title: Blood doi: 10.1182/blood-2011-03-338707 – ident: ref_46 doi: 10.1016/j.bspc.2024.106459 – volume: 30 start-page: 2532915 year: 2025 ident: ref_43 article-title: Analysis of risk factors for relapse after allogeneic hematopoietic stem cell transplantation in acute leukemia publication-title: Hematology doi: 10.1080/16078454.2025.2532915 – volume: 130 start-page: 285 year: 2017 ident: ref_36 article-title: CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies publication-title: Blood doi: 10.1182/blood-2017-01-761320 – volume: 6 start-page: 101989 year: 2025 ident: ref_10 article-title: Inflammatory reprogramming of the solid tumor microenvironment by infiltrating clonal hematopoiesis is associated with adverse outcomes publication-title: Cell Rep. Med. doi: 10.1016/j.xcrm.2025.101989 – volume: 66 start-page: e27481 year: 2018 ident: ref_23 article-title: Allogeneic hematopoietic cell transplantation in chemotherapy-induced aplasia in children with high-risk acute myeloid leukemia or myelodysplasia publication-title: Pediatr. Blood Cancer doi: 10.1002/pbc.27481 – volume: 34 start-page: 293 year: 2019 ident: ref_34 article-title: Daratumumab for eradication of minimal residual disease in high-risk advanced relapse of T-cell/CD19/CD22-negative acute lymphoblastic leukemia publication-title: Leukemia doi: 10.1038/s41375-019-0548-z – volume: 17 start-page: 771 year: 2011 ident: ref_7 article-title: Donor Cell Leukemia: A Review publication-title: Biol. Blood Marrow Transpl. doi: 10.1016/j.bbmt.2010.10.010 – volume: 18 start-page: 1126 year: 2017 ident: ref_26 article-title: Efficacy of two different doses of rabbit anti-T-lymphocyte globulin to prevent graft-versus-host disease in children with haematological malignancies transplanted from an unrelated donor: A multicentre, randomised, open-label, phase 3 trial publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(17)30417-5 – volume: 166 start-page: 209 year: 2014 ident: ref_5 article-title: Donor-derived myelodysplastic syndrome and acute leukaemia after allogeneic haematopoietic stem cell transplantation: Incidence, natural history and treatment response publication-title: Br. J. Haematol. doi: 10.1111/bjh.12847 – volume: 61 start-page: 712 year: 2013 ident: ref_22 article-title: Fludarabine, cytarabine, granulocyte colony-stimulating factor and melphalan (FALG with L-PAM) as a reduced toxicity conditioning regimen in children with acute leukemia publication-title: Pediatr. Blood Cancer doi: 10.1002/pbc.24922 – volume: 144 start-page: 107546 year: 2024 ident: ref_3 article-title: Updates in biology, classification, and management of acute myeloid leukemia with antecedent hematologic disorder and therapy related acute myeloid leukemia publication-title: Leuk. Res. doi: 10.1016/j.leukres.2024.107546 – ident: ref_45 doi: 10.1109/ICAIBD57115.2023.10206402 – volume: 130 start-page: 844 year: 2017 ident: ref_40 article-title: An Off-the-Shelf™ Fratricide-Resistant CAR-T for the Treatment of T Cell Hematologic Malignancies publication-title: Blood doi: 10.1182/blood.V130.Suppl_1.844.844 – volume: 1 start-page: 57 year: 2015 ident: ref_6 article-title: Donor Specific Antibody–Mediated Rejection in Allogeneic Hematopoietic Stem Cell Transplant Recipients publication-title: Hematol. Transfus. Int. J. – volume: 34 start-page: 17 year: 2015 ident: ref_18 article-title: Treosulfan-fludarabine-thiotepa conditioning before allogeneic haemopoietic stem cell transplantation for patients with advanced lympho-proliferative disease. A single centre study publication-title: Hematol. Oncol. doi: 10.1002/hon.2187 – volume: 2020 start-page: 494 year: 2020 ident: ref_35 article-title: CAR T cells for other pediatric non–B-cell hematologic malignancies publication-title: Hematology doi: 10.1182/hematology.2020000134 – volume: 9 start-page: 318 year: 2025 ident: ref_44 article-title: Comparison of Support Vector Machine and Decision Tree Algorithm Performance with Undersampling Approach in Predicting Heart Disease Based on Lifestyle publication-title: J. Appl. Inform. Comput. doi: 10.30871/jaic.v9i2.8941 – volume: 15 start-page: 809 year: 2014 ident: ref_28 article-title: Augmented post-remission therapy for a minimal residual disease-defined high-risk subgroup of children and young people with clinical standard-risk and intermediate-risk acute lymphoblastic leukaemia (UKALL 2003): A randomised controlled trial publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(14)70243-8 – volume: 122 start-page: 1995 year: 2013 ident: ref_41 article-title: Monitoring of Minimal Residual Disease After Allogeneic Stem Cell Transplantation in Relapsed Childhood ALL Allows the Identification of Impending Relapse-Results of the ALL BFM SCT 2003 Trial publication-title: Blood doi: 10.1182/blood.V122.21.1995.1995 – volume: 126 start-page: 983 year: 2015 ident: ref_37 article-title: A T-cell–directed chimeric antigen receptor for the selective treatment of T-cell malignancies publication-title: Blood doi: 10.1182/blood-2015-02-629527 – volume: 35 start-page: 3466 year: 2021 ident: ref_39 article-title: Base-edited CAR T cells for combinational therapy against T cell malignancies publication-title: Leukemia doi: 10.1038/s41375-021-01282-6 |
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| Title | Application of Graph Neural Networks to Model Stem Cell Donor–Recipient Compatibility in the Detection and Classification of Leukemia |
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