An Adaptive Model Predictive Controller to Address the Biovariability in Blood Clotting Response During Therapy With Warfarin

Objective: Effective dosing of anticoagulants aims to prevent blood clot formation while avoiding hemorrhages. This complex task is challenged by several disturbing factors and drug-effect uncertainties, requesting frequent monitoring and adjustment. Biovariability in drug absorption and action furt...

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Bibliographic Details
Published in:	IEEE transactions on biomedical engineering Vol. 70; no. 9; pp. 1 - 11
Main Authors:	Faggionato, Edoardo, Guazzo, Alessandro, Pegolo, Elena, Carli, Ruggero, Bruschetta, Mattia, Favero, Simone Del
Format:	Journal Article
Language:	English
Published:	United States IEEE 01.09.2023 The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects:	Adaptation models Adaptive algorithms Adaptive control Algorithms Anticoagulant Anticoagulants Bayesian analysis Biological system modeling Blood Blood coagulation Closed loops Clotting Coagulation Computational modeling Control algorithms Control systems design Control theory Controllers Drugs Feedback control Hemorrhage In-silico simulation Medical treatment Model-based control Precision medicine Predictive control Therapy Titration Warfarin
ISSN:	0018-9294, 1558-2531, 1558-2531
Online Access:	Get full text
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