An Adaptive Model Predictive Controller to Address the Biovariability in Blood Clotting Response During Therapy With Warfarin

Objective: Effective dosing of anticoagulants aims to prevent blood clot formation while avoiding hemorrhages. This complex task is challenged by several disturbing factors and drug-effect uncertainties, requesting frequent monitoring and adjustment. Biovariability in drug absorption and action furt...

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Vydáno v:	IEEE transactions on biomedical engineering Ročník 70; číslo 9; s. 1 - 11
Hlavní autoři:	Faggionato, Edoardo, Guazzo, Alessandro, Pegolo, Elena, Carli, Ruggero, Bruschetta, Mattia, Favero, Simone Del
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States IEEE 01.09.2023 The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Témata:	Adaptation models Adaptive algorithms Adaptive control Algorithms Anticoagulant Anticoagulants Bayesian analysis Biological system modeling Blood Blood coagulation Closed loops Clotting Coagulation Computational modeling Control algorithms Control systems design Control theory Controllers Drugs Feedback control Hemorrhage In-silico simulation Medical treatment Model-based control Precision medicine Predictive control Therapy Titration Warfarin
ISSN:	0018-9294, 1558-2531, 1558-2531
On-line přístup:	Získat plný text
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