Denitrogenative Hydrotrifluoromethylation of Benzaldehyde Hydrazones: Synthesis of (2,2,2‐Trifluoroethyl)arenes

Reacting hydrazones of arylaldehydes with Togni's CF 3 ‐benziodoxolone reagent, in the presence of potassium hydroxide and cesium fluoride, induces a denitrogenative hydrotrifluoromethylation event to produce (2,2,2‐trifluoroethyl)arenes. This novel reaction was tolerant to many electronically‐...

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Bibliographic Details
Published in:	Chemistry : a European journal Vol. 25; no. 48; pp. 11240 - 11245
Main Authors:	Zhao, Zhensheng, Ma, Kevin C. Y., Legault, Claude Y., Murphy, Graham K.
Format:	Journal Article
Language:	English
Published:	WEINHEIM Wiley 27.08.2019 Wiley Subscription Services, Inc
Subjects:	Aromatic compounds Benzaldehyde Cesium Cesium fluorides Chemistry Chemistry, Multidisciplinary Functional groups Hydrazones Physical Sciences Potassium hydroxide Potassium hydroxides Reagents Science & Technology Substitution reactions Substrates Transition metals hypervalent iodine NUCLEOPHILIC TRIFLUOROMETHYLATION C-H TRIFLUOROETHYLATION MOLECULAR CALCULATIONS Wolff-Kishner ARYLBORONIC ACIDS CROSS-COUPLING REACTIONS COPPER-CATALYZED TRIFLUOROMETHYLATION METAL-FREE TRIFLUOROMETHYLATION trifluoromethylation ORGANIC HALIDES ARYL IODIDES BASIS-SETS hydrazones fluorine
ISSN:	0947-6539, 1521-3765
Online Access:	Get full text
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