Denitrogenative Hydrotrifluoromethylation of Benzaldehyde Hydrazones: Synthesis of (2,2,2‐Trifluoroethyl)arenes

Reacting hydrazones of arylaldehydes with Togni's CF 3 ‐benziodoxolone reagent, in the presence of potassium hydroxide and cesium fluoride, induces a denitrogenative hydrotrifluoromethylation event to produce (2,2,2‐trifluoroethyl)arenes. This novel reaction was tolerant to many electronically‐...

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Veröffentlicht in:	Chemistry : a European journal Jg. 25; H. 48; S. 11240 - 11245
Hauptverfasser:	Zhao, Zhensheng, Ma, Kevin C. Y., Legault, Claude Y., Murphy, Graham K.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	WEINHEIM Wiley 27.08.2019 Wiley Subscription Services, Inc
Schlagworte:	Aromatic compounds Benzaldehyde Cesium Cesium fluorides Chemistry Chemistry, Multidisciplinary Functional groups Hydrazones Physical Sciences Potassium hydroxide Potassium hydroxides Reagents Science & Technology Substitution reactions Substrates Transition metals hypervalent iodine NUCLEOPHILIC TRIFLUOROMETHYLATION C-H TRIFLUOROETHYLATION MOLECULAR CALCULATIONS Wolff-Kishner ARYLBORONIC ACIDS CROSS-COUPLING REACTIONS COPPER-CATALYZED TRIFLUOROMETHYLATION METAL-FREE TRIFLUOROMETHYLATION trifluoromethylation ORGANIC HALIDES ARYL IODIDES BASIS-SETS hydrazones fluorine
ISSN:	0947-6539, 1521-3765
Online-Zugang:	Volltext
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