Anti–IL-4R versus anti–IL-5/5R after anti–IL-5/5R failure in asthma: An emulated target trial

[Display omitted] Switching biologics is now common practice in severe eosinophilic asthma. After insufficient response to anti–IL-5 or 5 receptor (anti–IL-5/5R), the optimal switch between an anti–IL-4R mAb (interclass) or another anti–IL-5/5R drug (intraclass) remains unknown. We sought to compare...

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Published in:	Journal of allergy and clinical immunology Vol. 154; no. 4; pp. 922 - 932
Main Authors:	Bonniaud, Philippe, Beurnier, Antoine, Boudjemaa, Amel, Bourdin, Arnaud, Maurer, C., Beurnier, A., Roux, P., Margelidon, V., Boudjemaa, A., Mangiapan, G., Freymond, N., Russier, M., Dupin, C., Maillard, S. Habib, Khayat, N., Li, X., Leroyer, C., Sattler, C., Guilleminault, L., Gaillot-Drevon, M., Martin, P., Chabrol, A., Pegliasco, H., Sése, L., Tcherakian, C., Ahmed, E., Tummino, C., Mourin, G., Drucbert, M., Keddache, S., Justet, A., Valcke, J., Mercy, M., Jouvenot, M., Godbert, B., Maitre, B., Goyard, C., Cadet, E., Mattei, L., Chauveau, S., Fry, S., Moui, A., Picart, G., Portel, L., Jean, R., Guillo, S., Estellat, C., Prigent, A., Jaffuel, D., Bourayou, Karima, Medina, Hadj Kaci, Djouher, Dahmani, Vacher, Yannick, Allibe, Flora, Barnig, Cindy, Chauveau, Simon, Didi, Toufik, Drucbert, Mélanie, Dupin, Clairelyne, Fouquet, Helen, Fry, Stéphanie, Gaillot-Drevon, Maud, Gamez, Anne Sophie, Garcia, Gilles, Gaspard, Wanda, Gicquello, Alice, Givel, Claire, Guilleminault, Laurent, Habib-Maillard, Stéphanie, Izadifar, Armine, Jouvenot, marie, Jouveshomme, Stéphane, Keddache, Sophia, Khayath, Naji, Leroyer, Christophe, Li, Xing, Magnan, Antoine, Maitre, Bernard, Maurer, Cyril, Michaux, Karine, Moui, Antoine, Oster, Jean-Philippe, Paleiron, Nicolas, Pegliasco, Hervé, Perrin, Julie, Picart, Gaël, Popin-Meyer, Élisabeth, Rami, Hassina, Serra, Mireille Rocca, Rochefort-Morel, Cécile, Romanet, Stéphanie, Rossignoli, Nadine, Russier, Maud, Saint-Raymond, Christel, Sattler, Caroline, Soumagne, Thibaud, Tcherakian, Colas, Tiotiu, Angélica, Vignal, Guillaume, Volpato, Mathilde
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.10.2024 Elsevier
Subjects:	Adult Anti-Asthmatic Agents Anti-Asthmatic Agents - therapeutic use Antibodies, Monoclonal Antibodies, Monoclonal - therapeutic use Asthma Asthma - drug therapy benralizumab dupilumab Female Human health and pathology Humans Interleukin-5 Interleukin-5 - antagonists & inhibitors Interleukin-5 - immunology Life Sciences Male Mepolizumab Middle Aged Randomized Controlled Trials as Topic Receptors, Interleukin-5 Receptors, Interleukin-5 - antagonists & inhibitors severe asthma Treatment Failure Treatment Outcome treatment switch BEC treatment switch OR RAMSES AQLQ Mepolizumab benralizumab SA dupilumab ACT severe asthma CRwNP OCS
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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