CD4 + CD25 + regulatory T cell therapy in neurological autoimmune diseases

CD4 + CD25 + regulatory T cells (Tregs) play a critical role in maintaining immune tolerance. They are essential for the initiation and progression of autoimmune diseases affecting the nervous system. Recently, the correlation between Tregs and neurological autoimmune diseases, as well as their ther...

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Published in:PeerJ (San Francisco, CA) Vol. 13; p. e19450
Main Authors: Yuan, Guobin, Liu, Ying, Wang, Hongquan, Yang, Tingting, Liu, Guangzhi
Format: Journal Article
Language:English
Published: United States PeerJ, Inc 12.06.2025
PeerJ Inc
Subjects:
Animals
Antigens
Autoimmune diseases
Autoimmune Diseases - immunology
Autoimmune Diseases - therapy
Autoimmune Diseases of the Nervous System - immunology
Autoimmune Diseases of the Nervous System - therapy
Bioengineering
CD25 antigen
CD4 antigen
Cell therapy
Cytokines
Guillain-Barre syndrome
Humans
Immune response
Immunological tolerance
Immunology
Immunoregulation
In vivo methods and tests
Interleukin-2 Receptor alpha Subunit - immunology
Lymphocytes
Lymphocytes T
Nervous system
Nervous System Diseases - immunology
Nervous System Diseases - therapy
Neurological autoimmune diseases
Neurology
Neuroscience
Regulatory T cell
T cell receptors
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - transplantation
Therapy
Thymus gland
Transcription factors
Nervous system
Cell therapy
Autoimmune diseases
Neurological autoimmune diseases
Regulatory T cell
ISSN:2167-8359, 2167-8359, 2376-5992
Online Access:Get full text
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Description
Summary:CD4 + CD25 + regulatory T cells (Tregs) play a critical role in maintaining immune tolerance. They are essential for the initiation and progression of autoimmune diseases affecting the nervous system. Recently, the correlation between Tregs and neurological autoimmune diseases, as well as their therapeutic potential, has become a central focus of research. Currently, various methods for in vivo or in vitro generation and expansion of CD4 + CD25 + Tregs are under investigation; however, their application in cellular therapy is anticipated to face additional challenges. This article primarily delves into the development and function of CD4 + CD25 + Tregs, the role of Tregs in neurological autoimmune disease pathology, basic methods for enhancing therapies, and recent advancements and challenges in cellular therapy for neurological autoimmune diseases.
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ISSN:2167-8359
2167-8359
2376-5992
DOI:10.7717/peerj.19450