CD4 + CD25 + regulatory T cell therapy in neurological autoimmune diseases
CD4 + CD25 + regulatory T cells (Tregs) play a critical role in maintaining immune tolerance. They are essential for the initiation and progression of autoimmune diseases affecting the nervous system. Recently, the correlation between Tregs and neurological autoimmune diseases, as well as their ther...
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| Vydáno v: | PeerJ (San Francisco, CA) Ročník 13; s. e19450 |
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| Médium: | Journal Article |
| Jazyk: | angličtina |
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12.06.2025
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| ISSN: | 2167-8359, 2167-8359, 2376-5992 |
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| Abstract | CD4 + CD25 + regulatory T cells (Tregs) play a critical role in maintaining immune tolerance. They are essential for the initiation and progression of autoimmune diseases affecting the nervous system. Recently, the correlation between Tregs and neurological autoimmune diseases, as well as their therapeutic potential, has become a central focus of research. Currently, various methods for in vivo or in vitro generation and expansion of CD4 + CD25 + Tregs are under investigation; however, their application in cellular therapy is anticipated to face additional challenges. This article primarily delves into the development and function of CD4 + CD25 + Tregs, the role of Tregs in neurological autoimmune disease pathology, basic methods for enhancing therapies, and recent advancements and challenges in cellular therapy for neurological autoimmune diseases. |
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| AbstractList | CD4 + CD25 + regulatory T cells (Tregs) play a critical role in maintaining immune tolerance. They are essential for the initiation and progression of autoimmune diseases affecting the nervous system. Recently, the correlation between Tregs and neurological autoimmune diseases, as well as their therapeutic potential, has become a central focus of research. Currently, various methods for in vivo or in vitro generation and expansion of CD4 + CD25 + Tregs are under investigation; however, their application in cellular therapy is anticipated to face additional challenges. This article primarily delves into the development and function of CD4 + CD25 + Tregs, the role of Tregs in neurological autoimmune disease pathology, basic methods for enhancing therapies, and recent advancements and challenges in cellular therapy for neurological autoimmune diseases. CD4 CD25 regulatory T cells (Tregs) play a critical role in maintaining immune tolerance. They are essential for the initiation and progression of autoimmune diseases affecting the nervous system. Recently, the correlation between Tregs and neurological autoimmune diseases, as well as their therapeutic potential, has become a central focus of research. Currently, various methods for or generation and expansion of CD4 CD25 Tregs are under investigation; however, their application in cellular therapy is anticipated to face additional challenges. This article primarily delves into the development and function of CD4 CD25 Tregs, the role of Tregs in neurological autoimmune disease pathology, basic methods for enhancing therapies, and recent advancements and challenges in cellular therapy for neurological autoimmune diseases. CD4+CD25+ regulatory T cells (Tregs) play a critical role in maintaining immune tolerance. They are essential for the initiation and progression of autoimmune diseases affecting the nervous system. Recently, the correlation between Tregs and neurological autoimmune diseases, as well as their therapeutic potential, has become a central focus of research. Currently, various methods for in vivo or in vitro generation and expansion of CD4+CD25+ Tregs are under investigation; however, their application in cellular therapy is anticipated to face additional challenges. This article primarily delves into the development and function of CD4+CD25+ Tregs, the role of Tregs in neurological autoimmune disease pathology, basic methods for enhancing therapies, and recent advancements and challenges in cellular therapy for neurological autoimmune diseases.CD4+CD25+ regulatory T cells (Tregs) play a critical role in maintaining immune tolerance. They are essential for the initiation and progression of autoimmune diseases affecting the nervous system. Recently, the correlation between Tregs and neurological autoimmune diseases, as well as their therapeutic potential, has become a central focus of research. Currently, various methods for in vivo or in vitro generation and expansion of CD4+CD25+ Tregs are under investigation; however, their application in cellular therapy is anticipated to face additional challenges. This article primarily delves into the development and function of CD4+CD25+ Tregs, the role of Tregs in neurological autoimmune disease pathology, basic methods for enhancing therapies, and recent advancements and challenges in cellular therapy for neurological autoimmune diseases. |
| ArticleNumber | e19450 |
| Author | Yuan, Guobin Wang, Hongquan Liu, Ying Liu, Guangzhi Yang, Tingting |
| Author_xml | – sequence: 1 givenname: Guobin surname: Yuan fullname: Yuan, Guobin organization: Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China – sequence: 2 givenname: Ying surname: Liu fullname: Liu, Ying organization: Department of Neurology, Beijing Shunyi Hospital, Beijing, China – sequence: 3 givenname: Hongquan surname: Wang fullname: Wang, Hongquan organization: Department of Geriatrics, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing, China – sequence: 4 givenname: Tingting surname: Yang fullname: Yang, Tingting organization: Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China – sequence: 5 givenname: Guangzhi surname: Liu fullname: Liu, Guangzhi organization: Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40525111$$D View this record in MEDLINE/PubMed |
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| Keywords | Nervous system Cell therapy Autoimmune diseases Neurological autoimmune diseases Regulatory T cell |
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| SubjectTerms | Animals Antigens Autoimmune diseases Autoimmune Diseases - immunology Autoimmune Diseases - therapy Autoimmune Diseases of the Nervous System - immunology Autoimmune Diseases of the Nervous System - therapy Bioengineering CD25 antigen CD4 antigen Cell therapy Cytokines Guillain-Barre syndrome Humans Immune response Immunological tolerance Immunology Immunoregulation In vivo methods and tests Interleukin-2 Receptor alpha Subunit - immunology Lymphocytes Lymphocytes T Nervous system Nervous System Diseases - immunology Nervous System Diseases - therapy Neurological autoimmune diseases Neurology Neuroscience Regulatory T cell T cell receptors T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - transplantation Therapy Thymus gland Transcription factors |
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| Title | CD4 + CD25 + regulatory T cell therapy in neurological autoimmune diseases |
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