Newly identified pathogens associated with periodontitis: a systematic review

There is substantial evidence supporting the role of certain oral bacteria species in the onset and progression of periodontitis. Nevertheless, results of independent-culture diagnostic methods introduced about a decade ago have pointed to the existence of new periodontal pathogens. However, the dat...

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Vydané v:	Journal of dental research Ročník 93; číslo 9; s. 846
Hlavní autori:	Pérez-Chaparro, P J, Gonçalves, C, Figueiredo, L C, Faveri, M, Lobão, E, Tamashiro, N, Duarte, P, Feres, M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.09.2014
Predmet:	Archaea - classification Bacteria - classification Bacteria - isolation & purification Bacteroidetes - classification Dental Plaque - microbiology Gram-Negative Anaerobic Bacteria - classification Gram-Negative Bacteria - classification Humans Periodontitis - microbiology Periodontium - microbiology Phylogeny Proteobacteria - classification Spirochaetales - classification microbiology Bacteria dental plaque Archaea DNA periodontal disease
ISSN:	1544-0591, 1544-0591
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Abstract	There is substantial evidence supporting the role of certain oral bacteria species in the onset and progression of periodontitis. Nevertheless, results of independent-culture diagnostic methods introduced about a decade ago have pointed to the existence of new periodontal pathogens. However, the data of these studies have not been evaluated together, which may generate some misunderstanding on the actual role of these microorganisms in the etiology of periodontitis. The aim of this systematic review was to determine the current weight of evidence for newly identified periodontal pathogens based on the results of "association" studies. This review was conducted and reported in accordance with the PRISMA statement. The MEDLINE, EMBASE, and Cochrane databases were searched up to September 2013 for studies (1) comparing microbial data of subgingival plaque samples collected from subjects with periodontitis and periodontal health and (2) evaluating at least 1 microorganism other than the already-known periodontal pathogens. From 1,450 papers identified, 41 studies were eligible. The data were extracted and registered in predefined piloted forms. The results suggested that there is moderate evidence in the literature to support the association of 17 species or phylotypes from the phyla Bacteroidetes, Candidatus Saccharibacteria, Firmicutes, Proteobacteria, Spirochaetes, and Synergistetes. The phylum Candidatus Saccharibacteria and the Archaea domain also seem to have an association with disease. These data point out the importance of previously unidentified species in the etiology of periodontitis and might guide future investigations on the actual role of these suspected new pathogens in the onset and progression of this infection.
AbstractList	There is substantial evidence supporting the role of certain oral bacteria species in the onset and progression of periodontitis. Nevertheless, results of independent-culture diagnostic methods introduced about a decade ago have pointed to the existence of new periodontal pathogens. However, the data of these studies have not been evaluated together, which may generate some misunderstanding on the actual role of these microorganisms in the etiology of periodontitis. The aim of this systematic review was to determine the current weight of evidence for newly identified periodontal pathogens based on the results of "association" studies. This review was conducted and reported in accordance with the PRISMA statement. The MEDLINE, EMBASE, and Cochrane databases were searched up to September 2013 for studies (1) comparing microbial data of subgingival plaque samples collected from subjects with periodontitis and periodontal health and (2) evaluating at least 1 microorganism other than the already-known periodontal pathogens. From 1,450 papers identified, 41 studies were eligible. The data were extracted and registered in predefined piloted forms. The results suggested that there is moderate evidence in the literature to support the association of 17 species or phylotypes from the phyla Bacteroidetes, Candidatus Saccharibacteria, Firmicutes, Proteobacteria, Spirochaetes, and Synergistetes. The phylum Candidatus Saccharibacteria and the Archaea domain also seem to have an association with disease. These data point out the importance of previously unidentified species in the etiology of periodontitis and might guide future investigations on the actual role of these suspected new pathogens in the onset and progression of this infection. There is substantial evidence supporting the role of certain oral bacteria species in the onset and progression of periodontitis. Nevertheless, results of independent-culture diagnostic methods introduced about a decade ago have pointed to the existence of new periodontal pathogens. However, the data of these studies have not been evaluated together, which may generate some misunderstanding on the actual role of these microorganisms in the etiology of periodontitis. The aim of this systematic review was to determine the current weight of evidence for newly identified periodontal pathogens based on the results of "association" studies. This review was conducted and reported in accordance with the PRISMA statement. The MEDLINE, EMBASE, and Cochrane databases were searched up to September 2013 for studies (1) comparing microbial data of subgingival plaque samples collected from subjects with periodontitis and periodontal health and (2) evaluating at least 1 microorganism other than the already-known periodontal pathogens. From 1,450 papers identified, 41 studies were eligible. The data were extracted and registered in predefined piloted forms. The results suggested that there is moderate evidence in the literature to support the association of 17 species or phylotypes from the phyla Bacteroidetes, Candidatus Saccharibacteria, Firmicutes, Proteobacteria, Spirochaetes, and Synergistetes. The phylum Candidatus Saccharibacteria and the Archaea domain also seem to have an association with disease. These data point out the importance of previously unidentified species in the etiology of periodontitis and might guide future investigations on the actual role of these suspected new pathogens in the onset and progression of this infection.There is substantial evidence supporting the role of certain oral bacteria species in the onset and progression of periodontitis. Nevertheless, results of independent-culture diagnostic methods introduced about a decade ago have pointed to the existence of new periodontal pathogens. However, the data of these studies have not been evaluated together, which may generate some misunderstanding on the actual role of these microorganisms in the etiology of periodontitis. The aim of this systematic review was to determine the current weight of evidence for newly identified periodontal pathogens based on the results of "association" studies. This review was conducted and reported in accordance with the PRISMA statement. The MEDLINE, EMBASE, and Cochrane databases were searched up to September 2013 for studies (1) comparing microbial data of subgingival plaque samples collected from subjects with periodontitis and periodontal health and (2) evaluating at least 1 microorganism other than the already-known periodontal pathogens. From 1,450 papers identified, 41 studies were eligible. The data were extracted and registered in predefined piloted forms. The results suggested that there is moderate evidence in the literature to support the association of 17 species or phylotypes from the phyla Bacteroidetes, Candidatus Saccharibacteria, Firmicutes, Proteobacteria, Spirochaetes, and Synergistetes. The phylum Candidatus Saccharibacteria and the Archaea domain also seem to have an association with disease. These data point out the importance of previously unidentified species in the etiology of periodontitis and might guide future investigations on the actual role of these suspected new pathogens in the onset and progression of this infection.
Author	Tamashiro, N Duarte, P Figueiredo, L C Pérez-Chaparro, P J Gonçalves, C Feres, M Faveri, M Lobão, E
Author_xml	– sequence: 1 givenname: P J surname: Pérez-Chaparro fullname: Pérez-Chaparro, P J organization: Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil – sequence: 2 givenname: C surname: Gonçalves fullname: Gonçalves, C organization: Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil – sequence: 3 givenname: L C surname: Figueiredo fullname: Figueiredo, L C organization: Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil – sequence: 4 givenname: M surname: Faveri fullname: Faveri, M organization: Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil – sequence: 5 givenname: E surname: Lobão fullname: Lobão, E organization: Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil – sequence: 6 givenname: N surname: Tamashiro fullname: Tamashiro, N organization: Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil – sequence: 7 givenname: P surname: Duarte fullname: Duarte, P organization: Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil – sequence: 8 givenname: M surname: Feres fullname: Feres, M email: mferes@ung.br organization: Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil mferes@ung.br
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25074492$$D View this record in MEDLINE/PubMed
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Keywords	microbiology Bacteria dental plaque Archaea DNA periodontal disease
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Snippet	There is substantial evidence supporting the role of certain oral bacteria species in the onset and progression of periodontitis. Nevertheless, results of...
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SubjectTerms	Archaea - classification Bacteria - classification Bacteria - isolation & purification Bacteroidetes - classification Dental Plaque - microbiology Gram-Negative Anaerobic Bacteria - classification Gram-Negative Bacteria - classification Humans Periodontitis - microbiology Periodontium - microbiology Phylogeny Proteobacteria - classification Spirochaetales - classification
Title	Newly identified pathogens associated with periodontitis: a systematic review
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