Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation

The metalloproteases meprin alpha and beta are expressed in several tissues, leukocytes, and cancer cells. In skin, meprins are located in separate layers of human epidermis indicating distinct physiological functions, supported by effects on cultured keratinocytes. Meprin beta induces a dramatic ch...

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Veröffentlicht in:	Biological chemistry Jg. 391; H. 4; S. 455
Hauptverfasser:	Ohler, Anke, Debela, Mekdes, Wagner, Susanne, Magdolen, Viktor, Becker-Pauly, Christoph
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Germany 01.04.2010
Schlagworte:	Amino Acid Sequence Enzyme Activation Enzyme Precursors - metabolism Humans Kallikreins - metabolism Metalloendopeptidases - chemistry Metalloendopeptidases - metabolism Skin - enzymology Skin - metabolism Substrate Specificity
ISSN:	1437-4315, 1437-4315
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