Tailoring properties of natural deep eutectic solvents with water to facilitate their applications

Previously it was demonstrated that natural deep eutectic solvents (NADES) are promising green solvents for the extraction of natural products. However, despite their potential, an obvious disadvantage of NADES is the high viscosity. Here we explored the dilution effect on the structures and physico...

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Veröffentlicht in:	Food chemistry Jg. 187; S. 14 - 19
Hauptverfasser:	Dai, Yuntao, Witkamp, Geert-Jan, Verpoorte, Robert, Choi, Young Hae
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 15.11.2015
Schlagworte:	Biological Products - analysis Chalcone - analogs & derivatives Chalcone - analysis Chemical Phenomena cosmetics drugs enzymatic reactions food processing Fourier transform infrared spectroscopy Glucosides - analysis hydrogen bonding Magnetic Resonance Spectroscopy nuclear magnetic resonance spectroscopy physicochemical properties quercetin Quercetin - analysis solvents Solvents - chemistry Spectroscopy, Fourier Transform Infrared Viscosity Water - chemistry Carthamin Hydrogen bonding Natural deep eutectic solvents Quercetin Stabilizing capacity Water content
ISSN:	0308-8146, 1873-7072, 1873-7072
Online-Zugang:	Volltext
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Abstract	Previously it was demonstrated that natural deep eutectic solvents (NADES) are promising green solvents for the extraction of natural products. However, despite their potential, an obvious disadvantage of NADES is the high viscosity. Here we explored the dilution effect on the structures and physicochemical properties of NADES and their improvements of applications using quercetin and carthamin. The results of FT-IR and (1)H NMR experiments demonstrated that there are intensive H-bonding interactions between the two components of NADES and dilution with water caused the interactions weaken gradually and even disappeared completely at around 50% (v/v) water addition. A small amount of water could reduce the viscosity of NADES to the range of water and increase the conductivity by up to 100 times for some NADES. This study provides the basis for modulating NADES in a controllable way for their applications in food processing, enzyme reactions, pharmaceuticals and cosmetics.
AbstractList	Previously it was demonstrated that natural deep eutectic solvents (NADES) are promising green solvents for the extraction of natural products. However, despite their potential, an obvious disadvantage of NADES is the high viscosity. Here we explored the dilution effect on the structures and physicochemical properties of NADES and their improvements of applications using quercetin and carthamin. The results of FT-IR and 1H NMR experiments demonstrated that there are intensive H-bonding interactions between the two components of NADES and dilution with water caused the interactions weaken gradually and even disappeared completely at around 50% (v/v) water addition. A small amount of water could reduce the viscosity of NADES to the range of water and increase the conductivity by up to 100 times for some NADES. This study provides the basis for modulating NADES in a controllable way for their applications in food processing, enzyme reactions, pharmaceuticals and cosmetics. Previously it was demonstrated that natural deep eutectic solvents (NADES) are promising green solvents for the extraction of natural products. However, despite their potential, an obvious disadvantage of NADES is the high viscosity. Here we explored the dilution effect on the structures and physicochemical properties of NADES and their improvements of applications using quercetin and carthamin. The results of FT-IR and (1)H NMR experiments demonstrated that there are intensive H-bonding interactions between the two components of NADES and dilution with water caused the interactions weaken gradually and even disappeared completely at around 50% (v/v) water addition. A small amount of water could reduce the viscosity of NADES to the range of water and increase the conductivity by up to 100 times for some NADES. This study provides the basis for modulating NADES in a controllable way for their applications in food processing, enzyme reactions, pharmaceuticals and cosmetics. Previously it was demonstrated that natural deep eutectic solvents (NADES) are promising green solvents for the extraction of natural products. However, despite their potential, an obvious disadvantage of NADES is the high viscosity. Here we explored the dilution effect on the structures and physicochemical properties of NADES and their improvements of applications using quercetin and carthamin. The results of FT-IR and (1)H NMR experiments demonstrated that there are intensive H-bonding interactions between the two components of NADES and dilution with water caused the interactions weaken gradually and even disappeared completely at around 50% (v/v) water addition. A small amount of water could reduce the viscosity of NADES to the range of water and increase the conductivity by up to 100 times for some NADES. This study provides the basis for modulating NADES in a controllable way for their applications in food processing, enzyme reactions, pharmaceuticals and cosmetics.Previously it was demonstrated that natural deep eutectic solvents (NADES) are promising green solvents for the extraction of natural products. However, despite their potential, an obvious disadvantage of NADES is the high viscosity. Here we explored the dilution effect on the structures and physicochemical properties of NADES and their improvements of applications using quercetin and carthamin. The results of FT-IR and (1)H NMR experiments demonstrated that there are intensive H-bonding interactions between the two components of NADES and dilution with water caused the interactions weaken gradually and even disappeared completely at around 50% (v/v) water addition. A small amount of water could reduce the viscosity of NADES to the range of water and increase the conductivity by up to 100 times for some NADES. This study provides the basis for modulating NADES in a controllable way for their applications in food processing, enzyme reactions, pharmaceuticals and cosmetics.
Author	Witkamp, Geert-Jan Dai, Yuntao Verpoorte, Robert Choi, Young Hae
Author_xml	– sequence: 1 givenname: Yuntao surname: Dai fullname: Dai, Yuntao – sequence: 2 givenname: Geert-Jan surname: Witkamp fullname: Witkamp, Geert-Jan – sequence: 3 givenname: Robert surname: Verpoorte fullname: Verpoorte, Robert – sequence: 4 givenname: Young Hae surname: Choi fullname: Choi, Young Hae
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25976992$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1039/c3gc40899j 10.1039/c3cp44299c 10.1016/j.foodchem.2014.02.155 10.1039/C4CC04661G 10.1039/c3ra46149a 10.1002/jrs.953 10.1021/ac400432p 10.1007/BF03246512 10.1039/c2cc31638b 10.1039/c003976d 10.1021/ja025790m 10.1246/cl.2004.1414 10.1271/bbb.61.1179 10.1021/ma047999l 10.1039/c2gc35660k 10.1002/anie.200905212 10.1002/anie.201001561 10.1016/S0040-4039(00)85786-X 10.1104/pp.111.178426 10.1021/la900552b 10.1016/j.aca.2012.12.019 10.1021/bm300200e 10.1021/sc500096j 10.1039/c0ob01011a
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References	Zhao (10.1016/j.foodchem.2015.03.123_b0120) 2011; 9 Francisco (10.1016/j.foodchem.2015.03.123_b0045) 2012; 14 Choi (10.1016/j.foodchem.2015.03.123_b0015) 2011; 156 Mamajanov (10.1016/j.foodchem.2015.03.123_b0070) 2010; 49 Barańska (10.1016/j.foodchem.2015.03.123_b0010) 2003; 34 Gutiérrez (10.1016/j.foodchem.2015.03.123_b0055) 2009; 25 Gutiérrez (10.1016/j.foodchem.2015.03.123_b0060) 2010; 49 Dai (10.1016/j.foodchem.2015.03.123_b0020) 2013; 766 Dai (10.1016/j.foodchem.2015.03.123_b0030) 2013; 85 Esquembre (10.1016/j.foodchem.2015.03.123_b0040) 2013; 15 Kohno (10.1016/j.foodchem.2015.03.123_b0065) 2012; 48 Mary (10.1016/j.foodchem.2015.03.123_b0075) 2009; 6 Takahashi (10.1016/j.foodchem.2015.03.123_b0100) 1982; 23 Xu (10.1016/j.foodchem.2015.03.123_b0115) 2005; 38 Paiva (10.1016/j.foodchem.2015.03.123_b0090) 2014; 2 Watanabe (10.1016/j.foodchem.2015.03.123_b0105) 1997; 61 Xia (10.1016/j.foodchem.2015.03.123_b0110) 2014; 4 Abe (10.1016/j.foodchem.2015.03.123_b0005) 2010; 12 Ogihara (10.1016/j.foodchem.2015.03.123_b0085) 2004; 33 Durand (10.1016/j.foodchem.2015.03.123_b0035) 2013; 15 Swatloski (10.1016/j.foodchem.2015.03.123_b0095) 2002; 124 Dai (10.1016/j.foodchem.2015.03.123_b0025) 2014; 159 Nardecchia (10.1016/j.foodchem.2015.03.123_b0080) 2012; 13 Gu (10.1016/j.foodchem.2015.03.123_b0050) 2014; 50
References_xml	– volume: 15 start-page: 2275 year: 2013 ident: 10.1016/j.foodchem.2015.03.123_b0035 article-title: Evaluation of deep eutectic solvent-water binary mixtures for lipase-catalyzed lipophilization of phenolic acids publication-title: Green Chemistry doi: 10.1039/c3gc40899j – volume: 15 start-page: 11248 year: 2013 ident: 10.1016/j.foodchem.2015.03.123_b0040 article-title: Thermal unfolding and refolding of lysozyme in deep eutectic solvents and their aqueous dilutions publication-title: Physical Chemistry Chemical Physics doi: 10.1039/c3cp44299c – volume: 159 start-page: 116 year: 2014 ident: 10.1016/j.foodchem.2015.03.123_b0025 article-title: Natural deep eutectic solvents providing enhanced stability of natural colorants from safflower (Carthamus tinctorius) publication-title: Food Chemistry doi: 10.1016/j.foodchem.2014.02.155 – volume: 50 start-page: 11749 year: 2014 ident: 10.1016/j.foodchem.2015.03.123_b0050 article-title: Deep eutectic solvents as novel extraction media for phenolic compounds from model oil publication-title: Chemical Communications doi: 10.1039/C4CC04661G – volume: 4 start-page: 10586 year: 2014 ident: 10.1016/j.foodchem.2015.03.123_b0110 article-title: Aqueous ionic liquids and deep eutectic solvents for cellulosic biomass pretreatment and saccharification publication-title: RSC Advances doi: 10.1039/c3ra46149a – volume: 34 start-page: 68 year: 2003 ident: 10.1016/j.foodchem.2015.03.123_b0010 article-title: Vibrational spectra of racemic and enantiomeric malic acids publication-title: Journal of Raman Spectroscopy doi: 10.1002/jrs.953 – volume: 85 start-page: 6272 year: 2013 ident: 10.1016/j.foodchem.2015.03.123_b0030 article-title: Natural deep eutectic solvents as new extraction media for phenolic metabolites in safflower publication-title: Analytic Chemistry doi: 10.1021/ac400432p – volume: 6 start-page: 138 year: 2009 ident: 10.1016/j.foodchem.2015.03.123_b0075 article-title: FT-IR, FT-Raman and SERS spectra of l-proline publication-title: Journal of the Iranian Chemical Society doi: 10.1007/BF03246512 – volume: 48 start-page: 7119 year: 2012 ident: 10.1016/j.foodchem.2015.03.123_b0065 article-title: Ionic liquid/water mixtures: From hostility to conciliation publication-title: Chemical Communications doi: 10.1039/c2cc31638b – volume: 12 start-page: 1274 year: 2010 ident: 10.1016/j.foodchem.2015.03.123_b0005 article-title: Extraction of polysaccharides from bran with phosphonate or phosphinate-derived ionic liquids under short mixing time and low temperature publication-title: Green Chemistry doi: 10.1039/c003976d – volume: 124 start-page: 4974 year: 2002 ident: 10.1016/j.foodchem.2015.03.123_b0095 article-title: Dissolution of cellose with ionic liquids publication-title: Journal of American Chemical Society doi: 10.1021/ja025790m – volume: 33 start-page: 1414 year: 2004 ident: 10.1016/j.foodchem.2015.03.123_b0085 article-title: Polarity measurement for ionic liquids containing dissociable protons publication-title: Chemistry Letters doi: 10.1246/cl.2004.1414 – volume: 61 start-page: 1179 year: 1997 ident: 10.1016/j.foodchem.2015.03.123_b0105 article-title: Separation and determination of yellow and red safflower pigments in food by capillary electrophoresis publication-title: Bioscience Biotechnology and Biochemistry doi: 10.1271/bbb.61.1179 – volume: 38 start-page: 1684 year: 2005 ident: 10.1016/j.foodchem.2015.03.123_b0115 article-title: Synthesis and self-assembly of donor–spacer–acceptor molecules. Liquid crystals formed by single-component “complexes” via intermolecular hydrogen-bonding interaction publication-title: Macromolecules doi: 10.1021/ma047999l – volume: 14 start-page: 2153 year: 2012 ident: 10.1016/j.foodchem.2015.03.123_b0045 article-title: New natural and renewable low transition temperature mixtures (LTTMs): Screening as solvents for lignocellulosic biomass processing publication-title: Green Chemistry doi: 10.1039/c2gc35660k – volume: 49 start-page: 2158 year: 2010 ident: 10.1016/j.foodchem.2015.03.123_b0060 article-title: Bacteria incorporation in deep-eutectic solvents through freeze-drying publication-title: Angewandte Chemie International Edition doi: 10.1002/anie.200905212 – volume: 49 start-page: 6310 year: 2010 ident: 10.1016/j.foodchem.2015.03.123_b0070 article-title: DNA and RNA in anhydrous media: Duplex, triplex, and G-quadruplex secondary structures in a deep eutectic solvent publication-title: Angewandte Chemie International Edition doi: 10.1002/anie.201001561 – volume: 23 start-page: 5163 year: 1982 ident: 10.1016/j.foodchem.2015.03.123_b0100 article-title: Constitution of two coloring matters in the flower petals of Carthamus tinctorius L publication-title: Tetrahedron Letters doi: 10.1016/S0040-4039(00)85786-X – volume: 156 start-page: 1701 year: 2011 ident: 10.1016/j.foodchem.2015.03.123_b0015 article-title: Are natural deep eutectic solvents the missing link in understanding cellular metabolism and physiology? publication-title: Plant Physiology doi: 10.1104/pp.111.178426 – volume: 25 start-page: 5509 year: 2009 ident: 10.1016/j.foodchem.2015.03.123_b0055 article-title: Freeze-drying of aqueous solutions of deep eutectic solvents: A suitable approach to deep eutectic suspensions of self-assembled structures publication-title: Langmuir doi: 10.1021/la900552b – volume: 766 start-page: 61 year: 2013 ident: 10.1016/j.foodchem.2015.03.123_b0020 article-title: Natural deep eutectic solvents as new potential media for green technology publication-title: Analytica Chimica Acta doi: 10.1016/j.aca.2012.12.019 – volume: 13 start-page: 2029 year: 2012 ident: 10.1016/j.foodchem.2015.03.123_b0080 article-title: Phase behavior of elastin-like synthetic recombinamers in deep eutectic solvents publication-title: Biomacromolecules doi: 10.1021/bm300200e – volume: 2 start-page: 1063 year: 2014 ident: 10.1016/j.foodchem.2015.03.123_b0090 article-title: Natural deep eutectic solvents – Solvents for the 21st century publication-title: ACS Sustainable Chemistry & Engineering doi: 10.1021/sc500096j – volume: 9 start-page: 1908 year: 2011 ident: 10.1016/j.foodchem.2015.03.123_b0120 article-title: New eutectic ionic liquids for lipase activation and enzymatic preparation of biodiesel publication-title: Organic & Biomolecular Chemistry doi: 10.1039/c0ob01011a
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Snippet	Previously it was demonstrated that natural deep eutectic solvents (NADES) are promising green solvents for the extraction of natural products. However,...
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SubjectTerms	Biological Products - analysis Chalcone - analogs & derivatives Chalcone - analysis Chemical Phenomena cosmetics drugs enzymatic reactions food processing Fourier transform infrared spectroscopy Glucosides - analysis hydrogen bonding Magnetic Resonance Spectroscopy nuclear magnetic resonance spectroscopy physicochemical properties quercetin Quercetin - analysis solvents Solvents - chemistry Spectroscopy, Fourier Transform Infrared Viscosity Water - chemistry
Title	Tailoring properties of natural deep eutectic solvents with water to facilitate their applications
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