Comprehensive sequencing of the LRRK2 gene in patients with familial Parkinson's disease from North Africa

The LRRK2 gene is a key player in Parkinson's disease (PD), however prevalence and pathogenicity of LRRK2 variants remain to be investigated in ethnically diverse populations. Herein, we performed comprehensive sequencing of the LRRK2 gene in 92 Tunisian probands with familial PD. We then perfo...

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Bibliographic Details
Published in:	Movement disorders Vol. 25; no. 13; pp. 2052 - 2058
Main Authors:	Jasinska-Myga, Barbara, Kachergus, Jennifer, Vilariño-Güell, Carles, Wider, Christian, Soto-Ortolaza, Alexandra I., Kefi, Mounir, Middleton, Lefkos T., Ishihara-Paul, Lianna, Gibson, Rachel A., Amouri, Rim, Yahmed, Samia Ben, Sassi, Samia Ben, Zouari, Mourad, Euch, Ghada El, Ross, Owen A., Hentati, Faycal, Farrer, Matthew J.
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.10.2010 Wiley
Subjects:	Adult Africa, Northern - ethnology Aged Aged, 80 and over Arab-Berbers Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Exons - genetics familial Parkinson's disease Family Health Female genetics Genotype Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 LRRK2 Male Medical sciences Middle Aged Mutation, Missense - genetics Neurology Parkinson's disease Parkinsonian Disorders - genetics Polymorphism, Single Nucleotide - genetics Protein-Serine-Threonine Kinases - genetics Sequence Analysis, DNA sequencing North Africa Africa Human Nervous system diseases Parkinson's disease Nucleotide sequence familial Parkinson's disease LRRK2 Parkinson disease Cerebral disorder Arab-Berbers Familial disease genetics Central nervous system disease Degenerative disease Sequencing Extrapyramidal syndrome
ISSN:	0885-3185, 1531-8257, 1531-8257
Online Access:	Get full text
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