Mutational landscape and patterns of clonal evolution in relapsed pediatric acute lymphoblastic leukemia

Relapse of acute lymphoblastic leukemia (ALL) remains a leading cause of childhood death. Prior studies have shown clonal mutations at relapse often arise from relapse-fated subclones that exist at diagnosis. However, the genomic landscape, evolutionary trajectories and mutational mechanisms driving...

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Vydáno v:	Blood cancer discovery Ročník 1; číslo 1; s. 96
Hlavní autoři:	Waanders, Esmé, Gu, Zhaohui, Dobson, Stephanie M, Antić, Željko, Crawford, Jeremy Chase, Ma, Xiaotu, Edmonson, Michael N, Payne-Turner, Debbie, van de Vorst, Maartje, Jongmans, Marjolijn C J, McGuire, Irina, Zhou, Xin, Wang, Jian, Shi, Lei, Pounds, Stanley, Pei, Deqing, Cheng, Cheng, Song, Guangchun, Fan, Yiping, Shao, Ying, Rusch, Michael, McCastlain, Kelly, Yu, Jiangyan, van Boxtel, Ruben, Blokzijl, Francis, Iacobucci, Ilaria, Roberts, Kathryn G, Wen, Ji, Wu, Gang, Ma, Jing, Easton, John, Neale, Geoffrey, Olsen, Scott R, Nichols, Kim E, Pui, Ching-Hon, Zhang, Jinghui, Evans, William E, Relling, Mary V, Yang, Jun J, Thomas, Paul G, Dick, John E, Kuiper, Roland P, Mullighan, Charles G
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.07.2020
Témata:	Child Clonal Evolution - genetics Genomics Humans Mutation Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Recurrence genomics neoepitopes clonal evolution acute lymphoblastic leukemia relapse hypermutation
ISSN:	2643-3249, 2643-3249
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