Translating genes into health

A major challenge for genomics is to provide clinical benefits to the genetically diverse human population. Genome science has achieved a catalog of mutations and informative SNPs. Next-generation sequencing is rapidly delivering thousands of complete human genomes, but understanding and applying ge...

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Vydané v:Nature genetics Ročník 45; číslo 1; s. 4 - 5
Hlavní autori: Kricka, Larry J, Di Resta, Chiara
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: New York Nature Publishing Group US 01.01.2013
Nature Publishing Group
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631/208/212/2301
692/308/575
Agriculture
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedical research
Biomedicine
Cancer
Cancer Research
Disease
Disease susceptibility
DNA sequencing
Gene Function
Genes
Genetic aspects
Genetic diversity
Genetic testing
Genome-Wide Association Study
Genomes
Genomics
Genotype-environment interactions
Handicapped accessibility
Human Genetics
Humans
Infectious diseases
Innovations
Malaria
Medical genetics
Medical practices
meeting-report
Methods
Nucleotide sequencing
Studies
Technological change
Tuberculosis
Vector-borne diseases
Italy
ISSN:1061-4036, 1546-1718, 1546-1718
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Abstract A major challenge for genomics is to provide clinical benefits to the genetically diverse human population. Genome science has achieved a catalog of mutations and informative SNPs. Next-generation sequencing is rapidly delivering thousands of complete human genomes, but understanding and applying genomic knowledge remains a daunting undertaking. These challenges and opportunities for genomic medicine were central themes of the Golden Helix Symposium held in Turin, Italy, 18–21 April 2012.
AbstractList Correlation of genomic signatures with therapeutic response will enable the treatment of appropriate patients at appropriate stages of illness in clinical trials, resulting in more effective drugs, as well as better dosing and monitoring.\n Genomic research can have a fundamental role in the understanding of population differences in disease prevalence, treatment response and the influence of gene-environment interactions and epigenomics on disease. The degree of susceptibility and the progression of some infectious diseases (for example, tuberculosis, malaria and AIDS) are influenced by the host genetic component. [...]finding susceptibility genes and identifying new pathways involved in pathogenesis should aid in combating these pathogens and in developing appropriate therapies while improving the efficacy of existing therapies.
A major challenge for genomics is to provide clinical benefits to the genetically diverse human population. Genome science has achieved a catalog of mutations and informative SNPs. Next-generation sequencing is rapidly delivering thousands of complete human genomes, but understanding and applying genomic knowledge remains a daunting undertaking. These challenges and opportunities for genomic medicine were central themes of the Golden Helix Symposium held in Turin, Italy, 18–21 April 2012.
A major challenge for genomics is to provide clinical benefits to the genetically diverse human population. Genome science has achieved a catalog of mutations and informative SNPs. Next-generation sequencing is rapidly delivering thousands of complete human genomes, but understanding and applying genomic knowledge remains a daunting undertaking. These challenges and opportunities for genomic medicine were central themes of the Golden Helix Symposium held in Turin, Italy, 18-21 April 2012.A major challenge for genomics is to provide clinical benefits to the genetically diverse human population. Genome science has achieved a catalog of mutations and informative SNPs. Next-generation sequencing is rapidly delivering thousands of complete human genomes, but understanding and applying genomic knowledge remains a daunting undertaking. These challenges and opportunities for genomic medicine were central themes of the Golden Helix Symposium held in Turin, Italy, 18-21 April 2012.
Audience Academic
Author Kricka, Larry J
Di Resta, Chiara
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  givenname: Chiara
  surname: Di Resta
  fullname: Di Resta, Chiara
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  organization: Chiara Di Resta is in the Genomic Unit for the Diagnosis of Human Pathologies at Vita-Salute San Raffaele University, Milan, Italy
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crossref_primary_10_1038_ng_2745
crossref_primary_10_1186_s12864_016_3346_2
crossref_primary_10_1016_j_clinbiochem_2019_04_010
crossref_primary_10_3389_fmed_2023_1267930
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Snippet A major challenge for genomics is to provide clinical benefits to the genetically diverse human population. Genome science has achieved a catalog of mutations...
Correlation of genomic signatures with therapeutic response will enable the treatment of appropriate patients at appropriate stages of illness in clinical...
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SubjectTerms 631/208/212/2301
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Animal Genetics and Genomics
Biomedical and Life Sciences
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Biomedicine
Cancer
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DNA sequencing
Gene Function
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Genetic diversity
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Genomes
Genomics
Genotype-environment interactions
Handicapped accessibility
Human Genetics
Humans
Infectious diseases
Innovations
Malaria
Medical genetics
Medical practices
meeting-report
Methods
Nucleotide sequencing
Studies
Technological change
Tuberculosis
Vector-borne diseases
Title Translating genes into health
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