Quantification of the sensitivity increase of a micro-high-performance liquid chromatography–electrospray ionization mass spectrometry system with decreasing column diameter

This study details the sensitivity achieved with capillary columns when used with a micro-HPLC–electrospray ionization MS system. It is comprised of two sections, the first is the comparative study of three columns, one of narrow-bore diameter and two of capillary diameter. The second section compar...

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Bibliographic Details
Published in:	Journal of Chromatography A Vol. 976; no. 1; pp. 11 - 18
Main Authors:	Legido-Quigley, C, Smith, N.W, Mallet, D
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Amsterdam Elsevier B.V 08.11.2002 Elsevier
Subjects:	Analysis Analytical chemistry Biological and medical sciences Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, High Pressure Liquid - methods Exact sciences and technology General pharmacology Medical sciences Other chromatographic methods Pharmacology. Drug treatments Sensitivity and Specificity Spectrometry, Mass, Electrospray Ionization - methods Spectrophotometry, Ultraviolet Sensitivity Liquid chromatography Column diameter Capillary column Corticosteroid Coupled method Bronchodilator Antiinflammatory agent Salmeterol HPLC chromatography β-Adrenergic receptor agonist Fluticasone Antiasthma agent Experimental study Electrospray Microbore column Reversed phase chromatography Mass spectrometry Diameter
ISSN:	0021-9673
Online Access:	Get full text
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