DNA damage remodels the MITF interactome to increase melanoma genomic instability

Since genome instability can drive cancer initiation and progression, cells have evolved highly effective and ubiquitous DNA damage response (DDR) programs. However, some cells (for example, in skin) are normally exposed to high levels of DNA-damaging agents. Whether such high-risk cells possess lin...

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Veröffentlicht in:	Genes & development Jg. 38; H. 1-2; S. 70
Hauptverfasser:	Binet, Romuald, Lambert, Jean-Philippe, Tomkova, Marketa, Tischfield, Samuel, Baggiolini, Arianna, Picaud, Sarah, Sarkar, Sovan, Louphrasitthiphol, Pakavarin, Dias, Diogo, Carreira, Suzanne, Humphrey, Timothy C, Fillipakopoulos, Panagis, White, Richard, Goding, Colin R
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.01.2024
Schlagworte:	DNA DNA Damage Genomic Instability - genetics Humans Melanoma - genetics Microphthalmia-Associated Transcription Factor - genetics DNA damage repair DNA replication E318K replication stress homologous recombination NBS1 melanoma MITF SUMOylation
ISSN:	1549-5477, 1549-5477
Online-Zugang:	Weitere Angaben
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