Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy

Immune-responsive gene 1 (IRG1) encodes aconitate decarboxylase (ACOD1) that catalyzes the production of itaconic acids (ITAs). The anti-inflammatory function of IRG1/ITA has been established in multiple pathogen models, but very little is known in cancer. Here, we show that IRG1 is expressed in tum...

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Bibliographic Details

Published in:	Science advances Vol. 9; no. 17; p. eadg0654
Main Authors:	Chen, Yu-Jia, Li, Guan-Nan, Li, Xian-Jing, Wei, Lin-Xing, Fu, Min-Jie, Cheng, Zhou-Li, Yang, Zhen, Zhu, Gui-Qi, Wang, Xu-Dong, Zhang, Cheng, Zhang, Jin-Ye, Sun, Yi-Ping, Saiyin, Hexige, Zhang, Jin, Liu, Wei-Ren, Zhu, Wen-Wei, Guan, Kun-Liang, Xiong, Yue, Yang, Yong, Ye, Dan, Chen, Lei-Lei
Format:	Journal Article
Language:	English
Published:	United States American Association for the Advancement of Science 28.04.2023
Subjects:	Animals Biomedicine and Life Sciences Cancer CD8-Positive T-Lymphocytes - metabolism Humans Hydro-Lyases - genetics Immunology Immunotherapy Macrophages - metabolism Mice Neoplasms - genetics Neoplasms - metabolism Neoplasms - therapy SciAdv r-articles Tumor-Associated Macrophages - metabolism
ISSN:	2375-2548, 2375-2548
Online Access:	Get full text
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