Association Between Increased Linezolid Plasma Concentrations and the Development of Severe Toxicity in Multidrug-Resistant Tuberculosis Treatment

Treatment of multidrug-resistant (MDR) tuberculosis with linezolid is characterized by high rates of adverse events. Evidence on therapeutic drug monitoring to predict drug toxicity is scarce. This study aimed to evaluate the association of linezolid trough concentrations with severe toxicity. We re...

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Bibliographic Details

Published in:	Clinical infectious diseases Vol. 76; no. 3; p. e947
Main Authors:	Eimer, Johannes, Fréchet-Jachym, Mathilde, Le Dû, Damien, Caumes, Eric, El-Helali, Najoua, Marigot-Outtandy, Dhiba, Mechai, Frédéric, Peytavin, Gilles, Pourcher, Valérie, Rioux, Christophe, Yazdanpanah, Yazdan, Robert, Jérôme, Guglielmetti, Lorenzo
Format:	Journal Article
Language:	English
Published:	United States 08.02.2023
Subjects:	Antitubercular Agents - adverse effects Drug Monitoring Humans Linezolid - adverse effects Retrospective Studies Tuberculosis, Multidrug-Resistant - drug therapy toxicity severe adverse events linezolid multidrug-resistant tuberculosis therapeutic drug monitoring
ISSN:	1537-6591, 1537-6591
Online Access:	Get more information
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