Small interfering RNA: Discovery, pharmacology and clinical development—An introductory review

Post‐transcriptional gene silencing targets and degrades mRNA transcripts, silencing the expression of specific genes. RNA interference technology, using synthetic structurally well‐defined short double‐stranded RNA (small interfering RNA [siRNA]), has advanced rapidly in recent years. This introduc...

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Bibliographic Details
Published in:	British journal of pharmacology Vol. 180; no. 21; pp. 2697 - 2720
Main Authors:	Ranasinghe, Priyanga, Addison, Melisande L., Dear, James W., Webb, David J.
Format:	Journal Article
Language:	English
Published:	London Blackwell Publishing Ltd 01.11.2023
Subjects:	Amyloidosis Bioavailability Chemical modification Gene expression Gene silencing Genetic disorders Hypercholesterolemia Hyperoxaluria Immune response Liver Nuclease Patient compliance Pharmacodynamics Pharmacokinetics Porphyria Primary hyperoxaluria RNA-mediated interference siRNA Transthyretin
ISSN:	0007-1188, 1476-5381, 1476-5381
Online Access:	Get full text
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