Ageing and multiple sclerosis
The factor that is most relevant and strongly associated with the clinical course of multiple sclerosis is chronological age. Very young patients exclusively have relapsing remitting disease, whereas those with later onset disease face a more rapid development of permanent disability. For people wit...
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| Vydáno v: | Lancet neurology Ročník 22; číslo 1; s. 66 - 77 |
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| Hlavní autoři: | , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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England
Elsevier Ltd
01.01.2023
Elsevier Limited |
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| ISSN: | 1474-4422, 1474-4465, 1474-4465 |
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| Abstract | The factor that is most relevant and strongly associated with the clinical course of multiple sclerosis is chronological age. Very young patients exclusively have relapsing remitting disease, whereas those with later onset disease face a more rapid development of permanent disability. For people with progressive multiple sclerosis, the poor response to current disease modifying therapies might be related to ageing in the immune system and CNS. Ageing is also associated with increased risks of side-effects caused by some multiple sclerosis therapies. Both somatic and reproductive ageing processes might contribute to development of progressive multiple sclerosis. Understanding the role of ageing in immune and neural cell function in patients with multiple sclerosis might be key to halting non-relapse-related progression. The growing literature on potential therapies that target senescent cells and ageing processes might provide effective strategies for remyelination and neuroprotection. |
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| AbstractList | The factor that is most relevant and strongly associated with the clinical course of multiple sclerosis is chronological age. Very young patients exclusively have relapsing remitting disease, whereas those with later onset disease face a more rapid development of permanent disability. For people with progressive multiple sclerosis, the poor response to current disease modifying therapies might be related to ageing in the immune system and CNS. Ageing is also associated with increased risks of side-effects caused by some multiple sclerosis therapies. Both somatic and reproductive ageing processes might contribute to development of progressive multiple sclerosis. Understanding the role of ageing in immune and neural cell function in patients with multiple sclerosis might be key to halting non-relapse-related progression. The growing literature on potential therapies that target senescent cells and ageing processes might provide effective strategies for remyelination and neuroprotection. The factor that is most relevant and strongly associated with the clinical course of multiple sclerosis is chronological age. Very young patients exclusively have relapsing remitting disease, whereas those with later onset disease face a more rapid development of permanent disability. For people with progressive multiple sclerosis, the poor response to current disease modifying therapies might be related to ageing in the immune system and CNS. Ageing is also associated with increased risks of side-effects caused by some multiple sclerosis therapies. Both somatic and reproductive ageing processes might contribute to development of progressive multiple sclerosis. Understanding the role of ageing in immune and neural cell function in patients with multiple sclerosis might be key to halting non-relapse-related progression. The growing literature on potential therapies that target senescent cells and ageing processes might provide effective strategies for remyelination and neuroprotection.The factor that is most relevant and strongly associated with the clinical course of multiple sclerosis is chronological age. Very young patients exclusively have relapsing remitting disease, whereas those with later onset disease face a more rapid development of permanent disability. For people with progressive multiple sclerosis, the poor response to current disease modifying therapies might be related to ageing in the immune system and CNS. Ageing is also associated with increased risks of side-effects caused by some multiple sclerosis therapies. Both somatic and reproductive ageing processes might contribute to development of progressive multiple sclerosis. Understanding the role of ageing in immune and neural cell function in patients with multiple sclerosis might be key to halting non-relapse-related progression. The growing literature on potential therapies that target senescent cells and ageing processes might provide effective strategies for remyelination and neuroprotection. Summary The factor that is most relevant and strongly associated with the clinical course of multiple sclerosis is chronological age. Very young patients exclusively have relapsing remitting disease, whereas those with later onset disease face a more rapid development of permanent disability. For people with progressive multiple sclerosis, the poor response to current disease modifying therapies might be related to ageing in the immune system and CNS. Ageing is also associated with increased risks of side-effects caused by some multiple sclerosis therapies. Both somatic and reproductive ageing processes might contribute to development of progressive multiple sclerosis. Understanding the role of ageing in immune and neural cell function in patients with multiple sclerosis might be key to halting non-relapse-related progression. The growing literature on potential therapies that target senescent cells and ageing processes might provide effective strategies for remyelination and neuroprotection. |
| Author | Hua, Le H Absinta, Martina Graves, Jennifer S Segal, Benjamin M Krysko, Kristen M Franklin, Robin J M |
| Author_xml | – sequence: 1 givenname: Jennifer S surname: Graves fullname: Graves, Jennifer S email: jgraves@health.ucsd.edu organization: Department of Neurosciences, University of California, San Diego, CA, USA – sequence: 2 givenname: Kristen M surname: Krysko fullname: Krysko, Kristen M organization: Division of Neurology, Department of Medicine, Li Ka Shing Knowledge Institute, St Michael's Hospital, University of Toronto, Toronto, ON, Canada – sequence: 3 givenname: Le H surname: Hua fullname: Hua, Le H organization: Department of Neurology, Cleveland Clinic, Lou Ruvo Center for Brain Health, Las Vegas, NV, USA – sequence: 4 givenname: Martina surname: Absinta fullname: Absinta, Martina organization: Department of Neurology, Johns Hopkins University, Baltimore, MD, USA – sequence: 5 givenname: Robin J M surname: Franklin fullname: Franklin, Robin J M organization: Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK – sequence: 6 givenname: Benjamin M surname: Segal fullname: Segal, Benjamin M organization: Department of Neurology and the Neuroscience Research Institute, The Ohio State University, Columbus, OH, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36216015$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Adults Age Aging Atrophy Biomarkers Brain research Disabled Persons Disease Progression Epidemiology Humans Immune system Lymphocytes Multiple sclerosis Multiple Sclerosis - therapy Multiple Sclerosis, Chronic Progressive - drug therapy Multiple Sclerosis, Relapsing-Remitting - drug therapy Myelination Neuroprotection Older people Pathology Pediatrics |
| Title | Ageing and multiple sclerosis |
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