Ageing and multiple sclerosis

The factor that is most relevant and strongly associated with the clinical course of multiple sclerosis is chronological age. Very young patients exclusively have relapsing remitting disease, whereas those with later onset disease face a more rapid development of permanent disability. For people wit...

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Vydané v:Lancet neurology Ročník 22; číslo 1; s. 66 - 77
Hlavní autori: Graves, Jennifer S, Krysko, Kristen M, Hua, Le H, Absinta, Martina, Franklin, Robin J M, Segal, Benjamin M
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Elsevier Ltd 01.01.2023
Elsevier Limited
Predmet:
Adults
Age
Aging
Atrophy
Biomarkers
Brain research
Disabled Persons
Disease Progression
Epidemiology
Humans
Immune system
Lymphocytes
Multiple sclerosis
Multiple Sclerosis - therapy
Multiple Sclerosis, Chronic Progressive - drug therapy
Multiple Sclerosis, Relapsing-Remitting - drug therapy
Myelination
Neuroprotection
Older people
Pathology
Pediatrics
ISSN:1474-4422, 1474-4465, 1474-4465
On-line prístup:Získať plný text
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Abstract The factor that is most relevant and strongly associated with the clinical course of multiple sclerosis is chronological age. Very young patients exclusively have relapsing remitting disease, whereas those with later onset disease face a more rapid development of permanent disability. For people with progressive multiple sclerosis, the poor response to current disease modifying therapies might be related to ageing in the immune system and CNS. Ageing is also associated with increased risks of side-effects caused by some multiple sclerosis therapies. Both somatic and reproductive ageing processes might contribute to development of progressive multiple sclerosis. Understanding the role of ageing in immune and neural cell function in patients with multiple sclerosis might be key to halting non-relapse-related progression. The growing literature on potential therapies that target senescent cells and ageing processes might provide effective strategies for remyelination and neuroprotection.
AbstractList The factor that is most relevant and strongly associated with the clinical course of multiple sclerosis is chronological age. Very young patients exclusively have relapsing remitting disease, whereas those with later onset disease face a more rapid development of permanent disability. For people with progressive multiple sclerosis, the poor response to current disease modifying therapies might be related to ageing in the immune system and CNS. Ageing is also associated with increased risks of side-effects caused by some multiple sclerosis therapies. Both somatic and reproductive ageing processes might contribute to development of progressive multiple sclerosis. Understanding the role of ageing in immune and neural cell function in patients with multiple sclerosis might be key to halting non-relapse-related progression. The growing literature on potential therapies that target senescent cells and ageing processes might provide effective strategies for remyelination and neuroprotection.
The factor that is most relevant and strongly associated with the clinical course of multiple sclerosis is chronological age. Very young patients exclusively have relapsing remitting disease, whereas those with later onset disease face a more rapid development of permanent disability. For people with progressive multiple sclerosis, the poor response to current disease modifying therapies might be related to ageing in the immune system and CNS. Ageing is also associated with increased risks of side-effects caused by some multiple sclerosis therapies. Both somatic and reproductive ageing processes might contribute to development of progressive multiple sclerosis. Understanding the role of ageing in immune and neural cell function in patients with multiple sclerosis might be key to halting non-relapse-related progression. The growing literature on potential therapies that target senescent cells and ageing processes might provide effective strategies for remyelination and neuroprotection.The factor that is most relevant and strongly associated with the clinical course of multiple sclerosis is chronological age. Very young patients exclusively have relapsing remitting disease, whereas those with later onset disease face a more rapid development of permanent disability. For people with progressive multiple sclerosis, the poor response to current disease modifying therapies might be related to ageing in the immune system and CNS. Ageing is also associated with increased risks of side-effects caused by some multiple sclerosis therapies. Both somatic and reproductive ageing processes might contribute to development of progressive multiple sclerosis. Understanding the role of ageing in immune and neural cell function in patients with multiple sclerosis might be key to halting non-relapse-related progression. The growing literature on potential therapies that target senescent cells and ageing processes might provide effective strategies for remyelination and neuroprotection.
Summary The factor that is most relevant and strongly associated with the clinical course of multiple sclerosis is chronological age. Very young patients exclusively have relapsing remitting disease, whereas those with later onset disease face a more rapid development of permanent disability. For people with progressive multiple sclerosis, the poor response to current disease modifying therapies might be related to ageing in the immune system and CNS. Ageing is also associated with increased risks of side-effects caused by some multiple sclerosis therapies. Both somatic and reproductive ageing processes might contribute to development of progressive multiple sclerosis. Understanding the role of ageing in immune and neural cell function in patients with multiple sclerosis might be key to halting non-relapse-related progression. The growing literature on potential therapies that target senescent cells and ageing processes might provide effective strategies for remyelination and neuroprotection.
Author Hua, Le H
Absinta, Martina
Graves, Jennifer S
Segal, Benjamin M
Krysko, Kristen M
Franklin, Robin J M
Author_xml – sequence: 1
  givenname: Jennifer S
  surname: Graves
  fullname: Graves, Jennifer S
  email: jgraves@health.ucsd.edu
  organization: Department of Neurosciences, University of California, San Diego, CA, USA
– sequence: 2
  givenname: Kristen M
  surname: Krysko
  fullname: Krysko, Kristen M
  organization: Division of Neurology, Department of Medicine, Li Ka Shing Knowledge Institute, St Michael's Hospital, University of Toronto, Toronto, ON, Canada
– sequence: 3
  givenname: Le H
  surname: Hua
  fullname: Hua, Le H
  organization: Department of Neurology, Cleveland Clinic, Lou Ruvo Center for Brain Health, Las Vegas, NV, USA
– sequence: 4
  givenname: Martina
  surname: Absinta
  fullname: Absinta, Martina
  organization: Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
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  givenname: Robin J M
  surname: Franklin
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  organization: Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK
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  givenname: Benjamin M
  surname: Segal
  fullname: Segal, Benjamin M
  organization: Department of Neurology and the Neuroscience Research Institute, The Ohio State University, Columbus, OH, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36216015$$D View this record in MEDLINE/PubMed
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Snippet The factor that is most relevant and strongly associated with the clinical course of multiple sclerosis is chronological age. Very young patients exclusively...
Summary The factor that is most relevant and strongly associated with the clinical course of multiple sclerosis is chronological age. Very young patients...
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StartPage 66
SubjectTerms Adults
Age
Aging
Atrophy
Biomarkers
Brain research
Disabled Persons
Disease Progression
Epidemiology
Humans
Immune system
Lymphocytes
Multiple sclerosis
Multiple Sclerosis - therapy
Multiple Sclerosis, Chronic Progressive - drug therapy
Multiple Sclerosis, Relapsing-Remitting - drug therapy
Myelination
Neuroprotection
Older people
Pathology
Pediatrics
Title Ageing and multiple sclerosis
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https://www.ncbi.nlm.nih.gov/pubmed/36216015
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https://www.proquest.com/docview/2723813613
Volume 22
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