Associations of oral fluid MMP‐8 with periodontitis in Swiss adult subjects

Objective MMP‐8 is a prominent collagenase in periodontal disease. This cross‐sectional study examined whether MMP‐8 levels in saliva and gingival crevicular fluid (GCF) are associated with periodontitis in a Swiss population. Subjects and Methods A total of 258 subjects (107 m, 151 f, mean age: 43....

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Veröffentlicht in:Oral diseases Jg. 24; H. 3; S. 449 - 455
Hauptverfasser: Mauramo, M, Ramseier, AM, Mauramo, E, Buser, A, Tervahartiala, T, Sorsa, T, Waltimo, T
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Denmark Wiley Subscription Services, Inc 01.04.2018
Schlagworte:
Adult
Area Under Curve
Biomarkers - metabolism
Bleeding
Body mass index
Bone marrow
Bone marrow transplantation
Collagen
Collagenase
Cross-Sectional Studies
Diagnosis
Female
gingival crevicular fluid
Gingival Crevicular Fluid - metabolism
Gum disease
Humans
Male
Matrix Metalloproteinase 8 - metabolism
Middle Aged
MMP‐8
normal population
oral fluid
Periodontal Index
Periodontitis
Periodontitis - diagnosis
Periodontitis - metabolism
ROC Curve
Saliva
Saliva - metabolism
Smoking
Statistical analysis
Switzerland
Teeth
Young Adult
saliva
gingival crevicular fluid
MMP-8
normal population
oral fluid
periodontitis
ISSN:1354-523X, 1601-0825, 1601-0825
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Zusammenfassung:Objective MMP‐8 is a prominent collagenase in periodontal disease. This cross‐sectional study examined whether MMP‐8 levels in saliva and gingival crevicular fluid (GCF) are associated with periodontitis in a Swiss population. Subjects and Methods A total of 258 subjects (107 m, 151 f, mean age: 43.5 yr; range: 21–58 yr) acquired from the Swiss bone marrow donor registry participated in the study. Saliva and GCF samples were collected from subjects followed by a thorough dental and periodontal examination. MMP‐8 levels were determined with immunofluorometric assay. Associations of MMP‐8 levels with periodontal diagnosis, probing pocket depth (PPD) and bleeding on probing were statistically analysed with Pearson chi‐square test, Spearman's rho and logistic regression analysis. Results MMP‐8 in GCF correlated with MMP‐8 in saliva (p < .001). Periodontitis was more common (p < .001) among subjects with high levels of MMP‐8 in saliva and/or GCF compared with subjects with low levels of MMP‐8. Higher MMP‐8 levels in GCF and saliva were associated with any periodontal diagnosis (mild, moderate or severe), greater PPD, and bleeding on probing (p < .05). When age, gender, smoking, body mass index, number of medications and decayed, missing and filled teeth were adjusted for, all observed associations remained statistically significant. The area under curve of receiver‐operating characteristic was 0.67 for saliva and 0.71 for GCF. Conclusion Elevated MMP‐8 levels both in saliva and GCF are associated with periodontitis in a normal adult population.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1354-523X
1601-0825
1601-0825
DOI:10.1111/odi.12769