Peripheral blood lymphocytes genetically modified to express the self/tumor antigen MAGE-A3 induce antitumor immune responses in cancer patients

Dendritic cell (DC) targeting in vivo has recently been shown to confer strong and protective cytotoxic T lymphocyte (CTL)-based immunity in tumor murine models. Our group has recently demonstrated in preclinical models that the infusion of genetically modified lymphocytes (GMLs) expressing the self...

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Veröffentlicht in:	Blood Jg. 113; H. 8; S. 1651
Hauptverfasser:	Fontana, Raffaella, Bregni, Marco, Cipponi, Arcadi, Raccosta, Laura, Rainelli, Cristina, Maggioni, Daniela, Lunghi, Francesca, Ciceri, Fabio, Mukenge, Sylvain, Doglioni, Claudio, Colau, Didier, Coulie, Pierre G, Bordignon, Claudio, Traversari, Catia, Russo, Vincenzo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 19.02.2009
Schlagworte:	Adoptive Transfer Animals Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Cancer Vaccines - administration & dosage Cancer Vaccines - adverse effects Cell Line, Tumor Chlorocebus aethiops COS Cells Genetic Therapy - methods Humans Hypersensitivity, Delayed - immunology Melanoma - immunology Melanoma - pathology Melanoma - therapy Neoplasm Proteins - genetics Neoplasm Proteins - immunology Neoplasm Staging Pilot Projects Skin Neoplasms - immunology Skin Neoplasms - pathology Skin Neoplasms - therapy T-Lymphocytes - cytology T-Lymphocytes - physiology T-Lymphocytes - transplantation Thymidine Kinase - genetics Thymidine Kinase - immunology Transfection
ISSN:	1528-0020, 1528-0020
Online-Zugang:	Weitere Angaben
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