Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes

A randomized trial involving patients with acute coronary syndromes showed that prasugrel was superior to ticagrelor with regard to the incidence of death, myocardial infarction, or stroke within 1 year, with no increased risk of bleeding.

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Bibliographic Details
Published in:The New England journal of medicine Vol. 381; no. 16; pp. 1524 - 1534
Main Authors: Schüpke, Stefanie, Neumann, Franz-Josef, Menichelli, Maurizio, Mayer, Katharina, Bernlochner, Isabell, Wöhrle, Jochen, Richardt, Gert, Liebetrau, Christoph, Witzenbichler, Bernhard, Antoniucci, David, Akin, Ibrahim, Bott-Flügel, Lorenz, Fischer, Marcus, Landmesser, Ulf, Katus, Hugo A, Sibbing, Dirk, Seyfarth, Melchior, Janisch, Marion, Boncompagni, Duino, Hilz, Raphaela, Rottbauer, Wolfgang, Okrojek, Rainer, Möllmann, Helge, Hochholzer, Willibald, Migliorini, Angela, Cassese, Salvatore, Mollo, Pasquale, Xhepa, Erion, Kufner, Sebastian, Strehle, Axel, Leggewie, Stefan, Allali, Abdelhakim, Ndrepepa, Gjin, Schühlen, Helmut, Angiolillo, Dominick J, Hamm, Christian W, Hapfelmeier, Alexander, Tölg, Ralph, Trenk, Dietmar, Schunkert, Heribert, Laugwitz, Karl-Ludwig, Kastrati, Adnan
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 17.10.2019
Subjects:
Acute Coronary Syndrome - drug therapy
Acute Coronary Syndrome - mortality
Acute Coronary Syndrome - therapy
Acute coronary syndromes
Aged
Bleeding
Cerebral infarction
Clinical trials
Coronary Thrombosis - epidemiology
Death
Drug dosages
Female
Heart attacks
Hemorrhage - chemically induced
Humans
Implants
Incidence
Kaplan-Meier Estimate
Male
Medical imaging
Middle Aged
Myocardial infarction
Myocardial Infarction - epidemiology
Myocardial Infarction - prevention & control
Percutaneous Coronary Intervention
Platelet Aggregation Inhibitors - adverse effects
Platelet Aggregation Inhibitors - therapeutic use
Prasugrel Hydrochloride - adverse effects
Prasugrel Hydrochloride - therapeutic use
Purinergic P2Y Receptor Antagonists - adverse effects
Purinergic P2Y Receptor Antagonists - therapeutic use
Stents
Stroke - epidemiology
Stroke - prevention & control
Thrombosis
Ticagrelor - adverse effects
Ticagrelor - therapeutic use
Germany
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Description
Summary:A randomized trial involving patients with acute coronary syndromes showed that prasugrel was superior to ticagrelor with regard to the incidence of death, myocardial infarction, or stroke within 1 year, with no increased risk of bleeding.
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1908973