Design, synthesis, and evaluation of substituted alkylindoles that activate G protein-coupled receptors distinct from the cannabinoid CB1 and CB2 receptors

The alkylindole (AI), WIN55212-2, modulates the activity of several proteins, including cannabinoid receptors 1 and 2 (CB1R, CB2R), and at least additional G protein-coupled receptor (GPCR) that remains uncharacterized with respect to its molecular identity and pharmacological profile. Evidence sugg...

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Bibliographic Details

Published in:	European journal of medicinal chemistry Vol. 249; p. 115123
Main Authors:	Kline, Toni, Xu, Cong, Kreitzer, Faith R., Hurst, Dow P., Eldeeb, Khalil M., Wager-Miller, Jim, Olivas, Kathleen, Hepburn, Seon A., Huffman, John W., Mackie, Ken, Howlett, Allyn C., Reggio, Patricia, Stella, Nephi
Format:	Journal Article
Language:	English
Published:	Elsevier Masson SAS 05.03.2023
Subjects:	Alkylindoles Cannabinoids G protein-coupled receptors Cannabinoids G protein-coupled receptors Alkylindoles
ISSN:	0223-5234, 1768-3254, 1768-3254
Online Access:	Get full text
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