Structure-guided design of a truncated heterobivalent chemical probe degrader of IRE1α

IRE1α is an ER protein involved in the unfolded protein response (UPR) and dysregulation of the ER stress pathway has been implicated in several diseases. Inhibitors of the cytoplasmic endonuclease or kinase domains of the enzyme have limited utility and targeted degradation would address additional...

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Veröffentlicht in:	RSC medicinal chemistry Jg. 16; H. 6; S. 246 - 2466
Hauptverfasser:	Zerfas, Breanna L, Liu, Yingpeng, Che, Jianwei, Donovan, Katherine A, Hatcher, John M, Huerta, Fidel, Metivier, Rebecca J, Nowak, Rados aw P, Ragosta, Leah, Tsang, Tiffany, Fischer, Eric S, Jones, Lyn H
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	CAMBRIDGE Royal Soc Chemistry 18.03.2025 RSC
Schlagworte:	Biochemistry & Molecular Biology Chemistry Chemistry, Medicinal Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology COMPLEX PROTEIN CEREBLON
ISSN:	2632-8682, 2632-8682
Online-Zugang:	Volltext
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