SIRT3-AMPK signaling pathway as a protective target in endothelial dysfunction of early sepsis

•We demonstrated that p-AMPK expression in the aorta increased in the early stage of sepsis.•Activation of AMPK protected the vascular endothelial function and improved survival in septic mice.•SIRT3 activated AMPK to counteract the role of NF-κB and NLRP3 pathways in the early stage of sepsis. Exte...

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Bibliographic Details
Published in:	International immunopharmacology Vol. 106; p. 108600
Main Authors:	Yu, Huilin, Liu, Qian, Chen, Guodong, Huang, Longxiang, Luo, Minghao, Lv, Dingyi, Luo, Suxin
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.05.2022 Elsevier BV
Subjects:	AMPK Aorta Cecum Endothelial cells Endothelial dysfunction Endothelium eNOS In vivo methods and tests Inflammation Kinases Lipopolysaccharides NF-κB protein Nitric oxide Nitric-oxide synthase Phosphorylation Protein kinase Sepsis Signal transduction Signaling SIRT3 Survival Umbilical vein Vascular tissue Endothelial dysfunction Sepsis AMPK eNOS SIRT3
ISSN:	1567-5769, 1878-1705, 1878-1705
Online Access:	Get full text
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