SIRT3-AMPK signaling pathway as a protective target in endothelial dysfunction of early sepsis

•We demonstrated that p-AMPK expression in the aorta increased in the early stage of sepsis.•Activation of AMPK protected the vascular endothelial function and improved survival in septic mice.•SIRT3 activated AMPK to counteract the role of NF-κB and NLRP3 pathways in the early stage of sepsis. Exte...

Ausführliche Beschreibung