Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure

In a randomized trial, more than 1100 patients with nonischemic heart failure (left ventricular ejection fraction ≤35%) were assigned either to receive or not to receive an ICD. At a median of 67.6 months, there was no significant difference in mortality between the two groups. In both European and...

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Published in:The New England journal of medicine Vol. 375; no. 13; pp. 1221 - 1230
Main Authors: Køber, Lars, Thune, Jens J, Nielsen, Jens C, Haarbo, Jens, Videbæk, Lars, Korup, Eva, Jensen, Gunnar, Hildebrandt, Per, Steffensen, Flemming H, Bruun, Niels E, Eiskjær, Hans, Brandes, Axel, Thøgersen, Anna M, Gustafsson, Finn, Egstrup, Kenneth, Videbæk, Regitze, Hassager, Christian, Svendsen, Jesper H, Høfsten, Dan E, Torp-Pedersen, Christian, Pehrson, Steen
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 29.09.2016
Subjects:
Aged
Cardiac Pacing, Artificial
Cardiovascular Diseases - mortality
Clinical trials
Coronary artery
Death
Death, Sudden, Cardiac - epidemiology
Defibrillators
Defibrillators, Implantable
Electrocardiography
Female
Follow-Up Studies
Health risk assessment
Heart diseases
Heart failure
Heart Failure, Systolic - therapy
Humans
Male
Middle Aged
Mortality
Stroke Volume
Transplants & implants
Ventricle
Denmark
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Summary:In a randomized trial, more than 1100 patients with nonischemic heart failure (left ventricular ejection fraction ≤35%) were assigned either to receive or not to receive an ICD. At a median of 67.6 months, there was no significant difference in mortality between the two groups. In both European and U.S. guidelines, prophylactic implantation of an implantable cardioverter–defibrillator (ICD) is a class 1 recommendation for patients with heart failure and reduced left ventricular systolic function. 1 , 2 However, the evidence for a benefit is much stronger for patients with ischemic heart disease than it is for patients with heart failure from other causes. Over the past two decades, ICD implantation has been shown to be associated with substantial reductions in the rate of sudden cardiac death and total mortality in patients with ischemic heart disease. 3 – 6 In the case of patients without ischemic heart disease, one trial . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1608029