Autophagy in kidney disease and aging: lessons from rodent models

Autophagy is a highly regulated lysosomal protein degradation pathway that removes protein aggregates and damaged or excess organelles to maintain intracellular homeostasis and cell integrity. Dysregulation of autophagy is involved in the pathogenesis of a variety of metabolic and age-related diseas...

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Published in:Kidney international Vol. 90; no. 5; pp. 950 - 964
Main Authors: Lenoir, Olivia, Tharaux, Pierre-Louis, Huber, Tobias B
Format: Journal Article
Language:English
Published: United States 01.11.2016
Subjects:
Aging - physiology
Animals
Autophagy
Kidney Diseases - physiopathology
endothelium
kidney
autophagy
polycystic kidney disease
kidney transplantation
podocyte
mTOR
acute kidney injury
aging
glomerulus
ISSN:1523-1755
Online Access:Get more information
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Abstract Autophagy is a highly regulated lysosomal protein degradation pathway that removes protein aggregates and damaged or excess organelles to maintain intracellular homeostasis and cell integrity. Dysregulation of autophagy is involved in the pathogenesis of a variety of metabolic and age-related diseases. Growing evidence suggests that autophagy is implicated in cell injury during renal diseases, both in the tubulointerstitial compartment and in glomeruli. Nevertheless, the impact of autophagy on renal disease progression and aging is still not fully understood. This review summarizes the recent advances in understanding the role of autophagy for kidney disease and aging.
AbstractList Autophagy is a highly regulated lysosomal protein degradation pathway that removes protein aggregates and damaged or excess organelles to maintain intracellular homeostasis and cell integrity. Dysregulation of autophagy is involved in the pathogenesis of a variety of metabolic and age-related diseases. Growing evidence suggests that autophagy is implicated in cell injury during renal diseases, both in the tubulointerstitial compartment and in glomeruli. Nevertheless, the impact of autophagy on renal disease progression and aging is still not fully understood. This review summarizes the recent advances in understanding the role of autophagy for kidney disease and aging.
Author Huber, Tobias B
Tharaux, Pierre-Louis
Lenoir, Olivia
Author_xml – sequence: 1
  givenname: Olivia
  surname: Lenoir
  fullname: Lenoir, Olivia
  organization: Paris Cardiovascular Research Centre-PARCC, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France
– sequence: 2
  givenname: Pierre-Louis
  surname: Tharaux
  fullname: Tharaux, Pierre-Louis
  email: pierre-louis.tharaux@inserm.fr
  organization: Paris Cardiovascular Research Centre-PARCC, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Nephrology Division, Georges Pompidou European Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; FRIAS, Freiburg Institute for Advanced Studies and Center for Biological System Analysis-ZBSA, Freiburg, Germany. Electronic address: pierre-louis.tharaux@inserm.fr
– sequence: 3
  givenname: Tobias B
  surname: Huber
  fullname: Huber, Tobias B
  email: tobias.huber@uniklinik-freiburg.de
  organization: FRIAS, Freiburg Institute for Advanced Studies and Center for Biological System Analysis-ZBSA, Freiburg, Germany; Department of Medicine IV, Faculty of Medicine, University of Freiburg, Germany; BIOSS Center for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, Freiburg, Germany; Center for Systems Biology (ZBSA), Albert-Ludwigs-University, Freiburg, Germany. Electronic address: tobias.huber@uniklinik-freiburg.de
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27325184$$D View this record in MEDLINE/PubMed
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Copyright Copyright © 2016 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
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Issue 5
Keywords endothelium
kidney
autophagy
polycystic kidney disease
kidney transplantation
podocyte
mTOR
acute kidney injury
aging
glomerulus
Language English
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Snippet Autophagy is a highly regulated lysosomal protein degradation pathway that removes protein aggregates and damaged or excess organelles to maintain...
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SubjectTerms Aging - physiology
Animals
Autophagy
Kidney Diseases - physiopathology
Title Autophagy in kidney disease and aging: lessons from rodent models
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