Autophagy in kidney disease and aging: lessons from rodent models

Autophagy is a highly regulated lysosomal protein degradation pathway that removes protein aggregates and damaged or excess organelles to maintain intracellular homeostasis and cell integrity. Dysregulation of autophagy is involved in the pathogenesis of a variety of metabolic and age-related diseas...

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Bibliographic Details
Published in:Kidney international Vol. 90; no. 5; pp. 950 - 964
Main Authors: Lenoir, Olivia, Tharaux, Pierre-Louis, Huber, Tobias B
Format: Journal Article
Language:English
Published: United States 01.11.2016
Subjects:
Aging - physiology
Animals
Autophagy
Kidney Diseases - physiopathology
endothelium
kidney
autophagy
polycystic kidney disease
kidney transplantation
podocyte
mTOR
acute kidney injury
aging
glomerulus
ISSN:1523-1755
Online Access:Get more information
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Summary:Autophagy is a highly regulated lysosomal protein degradation pathway that removes protein aggregates and damaged or excess organelles to maintain intracellular homeostasis and cell integrity. Dysregulation of autophagy is involved in the pathogenesis of a variety of metabolic and age-related diseases. Growing evidence suggests that autophagy is implicated in cell injury during renal diseases, both in the tubulointerstitial compartment and in glomeruli. Nevertheless, the impact of autophagy on renal disease progression and aging is still not fully understood. This review summarizes the recent advances in understanding the role of autophagy for kidney disease and aging.
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ISSN:1523-1755
DOI:10.1016/j.kint.2016.04.014