Chromatographic comparison of bupivacaine imprinted polymers prepared in crushed monolith, microsphere, silica-based composite and capillary monolith formats

A comprehensive comparison of five chromatographic stationary phases based on molecularly imprinted polymers is presented. Efficiency, imprinting factors, water compatibility and batch-to-batch reproducibility are discussed for crushed monolith, microspheres, two silica-based composites and capillar...

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Bibliographic Details
Published in:Journal of Chromatography A Vol. 1160; no. 1; pp. 215 - 226
Main Authors: Oxelbark, Joakim, Legido-Quigley, Cristina, Aureliano, Carla S.A., Titirici, Maria-Magdalena, Schillinger, Eric, Sellergren, Börje, Courtois, Julien, Irgum, Knut, Dambies, Laurent, Cormack, Peter A.G., Sherrington, David C., De Lorenzi, Ersilia
Format: Journal Article
Language:English
Published: Amsterdam Elsevier B.V 10.08.2007
Elsevier
Subjects:
Adsorption
Analysis
Analytical chemistry
Biological and medical sciences
Bupivacaine
Bupivacaine - chemistry
Capillary monolith
Chemistry
Chromatographic methods and physical methods associated with chromatography
Chromatography, Liquid - methods
Exact sciences and technology
Frontal chromatography
General pharmacology
Iniferter
Medical sciences
Microspheres
Molecularly imprinted polymers
Other chromatographic methods
Pharmacology. Drug treatments
Polymers - chemical synthesis
Polymers - chemistry
Porosity
Silicon Dioxide - chemistry
Microspheres
Molecularly imprinted polymers
Frontal chromatography
Bupivacaine
Iniferter
Capillary monolith
Capillary column
Performance evaluation
Microsphere
Monolithic column
Adsorption isotherm
HPLC chromatography
Retention factor
Composite material
Local anesthetic
Methacrylic acid copolymer
Preparation
Carboxamide
Organic amide
Silica gel
Molecular imprinting
Anilide
Comparative study
Stationary phase
ISSN:0021-9673
Online Access:Get full text
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Description
Summary:A comprehensive comparison of five chromatographic stationary phases based on molecularly imprinted polymers is presented. Efficiency, imprinting factors, water compatibility and batch-to-batch reproducibility are discussed for crushed monolith, microspheres, two silica-based composites and capillary monoliths, all imprinted with the local anaesthetic bupivacaine. Synthesis protocol and chromatographic test conditions have been kept fixed within certain limits, in order to provide further insight into the strengths and weaknesses of the different formats. Excluding microparticles, all formats give satisfactory performance, especially in aqueous mobile phases. An assessment of batch-to-batch reproducibility in different mobile phases adds further value to this comparison study.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0021-9673
DOI:10.1016/j.chroma.2007.05.057