Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes

Magnesium (Mg ) homeostasis is critical for metabolism. However, the genetic determinants of the renal handling of Mg , which is crucial for Mg homeostasis, and the potential influence on metabolic traits in the general population are unknown. We obtained plasma and urine parameters from 9099 indivi...

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Vydáno v:	Journal of the American Society of Nephrology Ročník 29; číslo 1; s. 335
Hlavní autoři:	Corre, Tanguy, Arjona, Francisco J, Hayward, Caroline, Youhanna, Sonia, de Baaij, Jeroen H F, Belge, Hendrica, Nägele, Nadine, Debaix, Huguette, Blanchard, Maxime G, Traglia, Michela, Harris, Sarah E, Ulivi, Sheila, Rueedi, Rico, Lamparter, David, Macé, Aurélien, Sala, Cinzia, Lenarduzzi, Stefania, Ponte, Belen, Pruijm, Menno, Ackermann, Daniel, Ehret, Georg, Baptista, Daniela, Polasek, Ozren, Rudan, Igor, Hurd, Toby W, Hastie, Nicholas D, Vitart, Veronique, Waeber, Geràrd, Kutalik, Zoltán, Bergmann, Sven, Vargas-Poussou, Rosa, Konrad, Martin, Gasparini, Paolo, Deary, Ian J, Starr, John M, Toniolo, Daniela, Vollenweider, Peter, Hoenderop, Joost G J, Bindels, René J M, Bochud, Murielle, Devuyst, Olivier
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.01.2018
Témata:	Adiposity - genetics ADP-Ribosylation Factors - genetics Animals Gene-Environment Interaction Genome-Wide Association Study GTP-Binding Proteins - genetics Homeostasis - genetics Humans Insulin - blood Insulin Resistance - genetics Kidney - metabolism Magnesium - administration & dosage Magnesium - blood Magnesium - urine Mice Obesity - genetics Phenotype Polymorphism, Single Nucleotide RNA, Messenger - metabolism TRPM Cation Channels - genetics Zebrafish Zebrafish Proteins - genetics Tubular transport Genetic determinants zebrafish Metabolic syndrome Gene-environment interaction Magnesium homeostasis
ISSN:	1533-3450, 1533-3450
On-line přístup:	Zjistit podrobnosti o přístupu
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