Azithromycin to Reduce Childhood Mortality in Sub-Saharan Africa

Childhood mortality remains high in sub-Saharan Africa. In this cluster-randomized, placebo-controlled trial, mortality among children younger than 5 years of age was lower among those who received azithromycin than among those who received placebo.

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Bibliographic Details
Published in:The New England journal of medicine Vol. 378; no. 17; pp. 1583 - 1592
Main Authors: Keenan, Jeremy D, Bailey, Robin L, West, Sheila K, Arzika, Ahmed M, Hart, John, Weaver, Jerusha, Kalua, Khumbo, Mrango, Zakayo, Ray, Kathryn J, Cook, Catherine, Lebas, Elodie, O’Brien, Kieran S, Emerson, Paul M, Porco, Travis C, Lietman, Thomas M
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 26.04.2018
Subjects:
Administration, Oral
Anti-Bacterial Agents - therapeutic use
Antibiotic resistance
Antibiotics
Azithromycin
Azithromycin - therapeutic use
Body weight
Child mortality
Child Mortality - trends
Child, Preschool
Childhood
Children
Communicable Disease Control
Communicable Diseases - mortality
Confidence intervals
Drug Resistance, Bacterial
Female
Humans
Infant
Infant Mortality - trends
Intervention
Malawi - epidemiology
Male
Mass Drug Administration - mortality
Maternal & child health
Mortality
Niger - epidemiology
Preschool children
Public Health
Streptococcus infections
Sustainable development
Tanzania - epidemiology
Malawi
Niger
Sub-Saharan Africa
Tanzania
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Description
Summary:Childhood mortality remains high in sub-Saharan Africa. In this cluster-randomized, placebo-controlled trial, mortality among children younger than 5 years of age was lower among those who received azithromycin than among those who received placebo.
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1715474