3-Hydroxybenzo[a]pyrene in the urine of smokers and non-smokers

The people studied were male volunteers without occupational and dietary exposure to PAH: 27 smokers (10 cigarettes or more) and 27 non-smokers matched for age and socio-professional category. For each person, all the 24 h voided urine samples were reassembled in a single sample. 1-Hydroxypyrene (1-...

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Veröffentlicht in:Toxicology letters Jg. 162; H. 2; S. 181 - 185
Hauptverfasser: Lafontaine, M., Champmartin, C., Simon, P., Delsaut, P., Funck-Brentano, C.
Format: Journal Article Tagungsbericht
Sprache:Englisch
Veröffentlicht: Shannon Elsevier Ireland Ltd 10.04.2006
Amsterdam Elsevier Science
Schlagworte:
3-Hydroxybenzo[a]pyrene
Adult
Benzopyrenes - metabolism
Biological and medical sciences
Biomarkers - urine
Environmental exposure to PAH
Environmental Monitoring
Humans
Male
Medical sciences
Middle Aged
Occupational Exposure
Pyrenes - metabolism
Smokers
Smoking - urine
Toxicology
3-Hydroxybenzo[a]pyrene
Environmental exposure to PAH
Smokers
Human
Non smoker
Urine
Biological fluid
Pyrene
Smoker
Environment
Exposure
Polycyclic aromatic compound
ISSN:0378-4274, 1879-3169
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Zusammenfassung:The people studied were male volunteers without occupational and dietary exposure to PAH: 27 smokers (10 cigarettes or more) and 27 non-smokers matched for age and socio-professional category. For each person, all the 24 h voided urine samples were reassembled in a single sample. 1-Hydroxypyrene (1-OHPy) and 3-hydroxybenzo[a]pyrene (3-OHBaP) were then determined by automated column-switching high-performance liquid chromatography. Urinary 1-OHPy ranged from 0.041 to 0.530 μmol/molCreatinine (arithmetic mean 0.144, median 0.115) for smokers and from 0.01 to 0.148 μmol/molCreatinine (arithmetic mean 0.044, median 0.032) for non-smokers. These values are close to those of some other studies. Urinary 3-OHBaP ranged from <0.01 to 0.084 nmol/molCreatinine (arithmetic mean 0.030, median 0.023) for smokers and from <0.01 to 0.045 nmol/molCreatinine (arithmetic mean 0.014, median 0.011) for non-smokers. Considering more particularly the urinary 3-OHBaP values, the influence of smoking could be important among workers exposed to low levels of BaP (<100 ng/m 3) and the concentrations for smokers were equivalent to most of the preshift values of exposed workers. The dietary BaP intake was slightly lower than the BaP intake for an average smoker. From the present study, temporary basic reference levels may be proposed for urinary 3-OHBaP.
Bibliographie:ObjectType-Article-1
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content type line 23
ISSN:0378-4274
1879-3169
DOI:10.1016/j.toxlet.2005.09.019