Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis

In this randomized, controlled trial conducted at Danish cardiac centers, intravenous antibiotic therapy was compared with partial oral antibiotic therapy for the treatment of bacterial endocarditis. The outcomes were similar in the two groups.

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Bibliographic Details
Published in:The New England journal of medicine Vol. 380; no. 5; pp. 415 - 424
Main Authors: Iversen, Kasper, Ihlemann, Nikolaj, Gill, Sabine U, Madsen, Trine, Elming, Hanne, Jensen, Kaare T, Bruun, Niels E, Høfsten, Dan E, Fursted, Kurt, Christensen, Jens J, Schultz, Martin, Klein, Christine F, Fosbøll, Emil L, Rosenvinge, Flemming, Schønheyder, Henrik C, Køber, Lars, Torp-Pedersen, Christian, Helweg-Larsen, Jannik, Tønder, Niels, Moser, Claus, Bundgaard, Henning
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 31.01.2019
Subjects:
Administration, Intravenous
Administration, Oral
Aged
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - pharmacokinetics
Antibiotics
Bacteremia
Bacteremia - drug therapy
Cardiology
Coagulase
Endocarditis
Endocarditis, Bacterial - drug therapy
Endocarditis, Bacterial - microbiology
Endocarditis, Bacterial - mortality
Female
Heart
Heart surgery
Heart Valve Prosthesis - microbiology
Hospitals
Humans
Intention to Treat Analysis
Intravenous administration
Kaplan-Meier Estimate
Length of Stay
Male
Middle Aged
Patients
Recurrence
Society
Surgery
Denmark
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Description
Summary:In this randomized, controlled trial conducted at Danish cardiac centers, intravenous antibiotic therapy was compared with partial oral antibiotic therapy for the treatment of bacterial endocarditis. The outcomes were similar in the two groups.
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1808312