From podocyte biology to novel cures for glomerular disease
The podocyte is a key component of the glomerular filtration barrier. Podocyte dysfunction is central to the underlying pathophysiology of many common glomerular diseases, including diabetic nephropathy, glomerulonephritis and genetic forms of nephrotic syndrome. Collectively, these conditions affec...
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| Published in: | Kidney international Vol. 96; no. 4; p. 850 |
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| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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United States
01.10.2019
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| ISSN: | 1523-1755, 1523-1755 |
| Online Access: | Get more information |
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| Abstract | The podocyte is a key component of the glomerular filtration barrier. Podocyte dysfunction is central to the underlying pathophysiology of many common glomerular diseases, including diabetic nephropathy, glomerulonephritis and genetic forms of nephrotic syndrome. Collectively, these conditions affect millions of people worldwide, and account for the majority of kidney diseases requiring dialysis and transplantation. The 12th International Podocyte Conference was held in Montreal, Canada from May 30 to June 2, 2018. The primary aim of this conference was to bring together nephrologists, clinician scientists, basic scientists and their trainees from all over the world to present their research and to establish networks with the common goal of developing new therapies for glomerular diseases based on the latest advances in podocyte biology. This review briefly highlights recent advances made in understanding podocyte structure and metabolism, experimental systems in which to study podocytes and glomerular disease, disease mediators, genetic and immune origins of glomerulopathies, and the development of novel therapeutic agents to protect podocyte and glomerular injury. |
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| AbstractList | The podocyte is a key component of the glomerular filtration barrier. Podocyte dysfunction is central to the underlying pathophysiology of many common glomerular diseases, including diabetic nephropathy, glomerulonephritis and genetic forms of nephrotic syndrome. Collectively, these conditions affect millions of people worldwide, and account for the majority of kidney diseases requiring dialysis and transplantation. The 12th International Podocyte Conference was held in Montreal, Canada from May 30 to June 2, 2018. The primary aim of this conference was to bring together nephrologists, clinician scientists, basic scientists and their trainees from all over the world to present their research and to establish networks with the common goal of developing new therapies for glomerular diseases based on the latest advances in podocyte biology. This review briefly highlights recent advances made in understanding podocyte structure and metabolism, experimental systems in which to study podocytes and glomerular disease, disease mediators, genetic and immune origins of glomerulopathies, and the development of novel therapeutic agents to protect podocyte and glomerular injury.The podocyte is a key component of the glomerular filtration barrier. Podocyte dysfunction is central to the underlying pathophysiology of many common glomerular diseases, including diabetic nephropathy, glomerulonephritis and genetic forms of nephrotic syndrome. Collectively, these conditions affect millions of people worldwide, and account for the majority of kidney diseases requiring dialysis and transplantation. The 12th International Podocyte Conference was held in Montreal, Canada from May 30 to June 2, 2018. The primary aim of this conference was to bring together nephrologists, clinician scientists, basic scientists and their trainees from all over the world to present their research and to establish networks with the common goal of developing new therapies for glomerular diseases based on the latest advances in podocyte biology. This review briefly highlights recent advances made in understanding podocyte structure and metabolism, experimental systems in which to study podocytes and glomerular disease, disease mediators, genetic and immune origins of glomerulopathies, and the development of novel therapeutic agents to protect podocyte and glomerular injury. The podocyte is a key component of the glomerular filtration barrier. Podocyte dysfunction is central to the underlying pathophysiology of many common glomerular diseases, including diabetic nephropathy, glomerulonephritis and genetic forms of nephrotic syndrome. Collectively, these conditions affect millions of people worldwide, and account for the majority of kidney diseases requiring dialysis and transplantation. The 12th International Podocyte Conference was held in Montreal, Canada from May 30 to June 2, 2018. The primary aim of this conference was to bring together nephrologists, clinician scientists, basic scientists and their trainees from all over the world to present their research and to establish networks with the common goal of developing new therapies for glomerular diseases based on the latest advances in podocyte biology. This review briefly highlights recent advances made in understanding podocyte structure and metabolism, experimental systems in which to study podocytes and glomerular disease, disease mediators, genetic and immune origins of glomerulopathies, and the development of novel therapeutic agents to protect podocyte and glomerular injury. |
| Author | Torban, Elena Huber, Tobias B Takano, Tomoko Goodyer, Paul R Lennon, Rachel Ronco, Pierre Cybulsky, Andrey V Wanner, Nicola Braun, Fabian |
| Author_xml | – sequence: 1 givenname: Elena surname: Torban fullname: Torban, Elena email: elena.torban@mcgill.ca organization: Department of Medicine, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada. Electronic address: elena.torban@mcgill.ca – sequence: 2 givenname: Fabian surname: Braun fullname: Braun, Fabian organization: III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany – sequence: 3 givenname: Nicola surname: Wanner fullname: Wanner, Nicola organization: III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany – sequence: 4 givenname: Tomoko surname: Takano fullname: Takano, Tomoko organization: Department of Medicine, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada – sequence: 5 givenname: Paul R surname: Goodyer fullname: Goodyer, Paul R organization: Department of Pediatrics, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada – sequence: 6 givenname: Rachel surname: Lennon fullname: Lennon, Rachel organization: Wellcome Centre for Cell-Matrix Research, University of Manchester, Manchester, UK – sequence: 7 givenname: Pierre surname: Ronco fullname: Ronco, Pierre organization: Sorbonne University, INSERM UMR_S 1155, and Nephrology and Dialysis Department, Hôpital Tenon, Paris France – sequence: 8 givenname: Andrey V surname: Cybulsky fullname: Cybulsky, Andrey V organization: Department of Medicine, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada – sequence: 9 givenname: Tobias B surname: Huber fullname: Huber, Tobias B email: t.huber@uke.de organization: III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: t.huber@uke.de |
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