Neurotoxicity with high-dose disulfiram and vorinostat used for HIV latency reversal

The aim of this study was to examine whether administering both vorinostat and disulfiram to people with HIV (PWH) on antiretroviral therapy (ART) is well tolerated and can enhance HIV latency reversal. Vorinostat and disulfiram can increase HIV transcription in PWH on ART. Together, these agents ma...

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Vydané v:	AIDS (London) Ročník 36; číslo 1; s. 75
Hlavní autori:	McMahon, James H, Evans, Vanessa A, Lau, Jillian S Y, Symons, Jori, Zerbato, Jennifer M, Chang, Judy, Solomon, Ajantha, Tennakoon, Surekha, Dantanarayana, Ashanti, Hagenauer, Michelle, Lee, Sulggi, Palmer, Sarah, Fisher, Katie, Bumpus, Namandje, Heck, Carley J S, Burger, David, Wu, Guoxin, Zuck, Paul, Howell, Bonnie J, Zetterberg, Henrik H, Blennow, Kaj, Gisslen, Magnus, Rasmussen, Thomas A, Lewin, Sharon R
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 01.01.2022
Predmet:	Disulfiram - administration & dosage Drug Therapy, Combination - adverse effects HIV Infections - drug therapy Humans Virus Latency - physiology Vorinostat - administration & dosage
ISSN:	1473-5571, 1473-5571
On-line prístup:	Zistit podrobnosti o prístupe
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