Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates

Pathogenic mycobacteria pose a sustained threat to global human health. Recently, cytochrome bcc complexes have gained interest as targets for antibiotic drug development. However, there is currently no structural information for the cytochrome bcc complex from these pathogenic mycobacteria. Here, w...

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Veröffentlicht in:	eLife Jg. 10
Hauptverfasser:	Zhou, Shan, Wang, Weiwei, Zhou, Xiaoting, Zhang, Yuying, Lai, Yuezheng, Tang, Yanting, Xu, Jinxu, Li, Dongmei, Lin, Jianping, Yang, Xiaolin, Ran, Ting, Chen, Hongming, Guddat, Luke W, Wang, Quan, Gao, Yan, Rao, Zihe, Gong, Hongri
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England eLife Sciences Publications Ltd 25.11.2021 eLife Sciences Publications, Ltd
Schlagworte:	Adenosine triphosphate Antibiotics Antitubercular Agents - pharmacology Bacterial Proteins - chemistry cryo-electron microscopy Cryoelectron Microscopy Cytochrome cytochrome bcc complex Cytochromes - chemistry Data processing Drug Development Electron microscopy Homeostasis Hydrogen bonding Hydroquinone Imidazoles - pharmacology Infections Leprosy Menaquinones Microscopy Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Piperidines - pharmacology Pyridines - pharmacology Q203 Quinones Structural Biology and Molecular Biophysics TB47 Tuberculosis Q203 Mycobacterium tuberculosis cytochrome bcc complex TB47 structural biology molecular biophysics cryo-electron microscopy
ISSN:	2050-084X, 2050-084X
Online-Zugang:	Volltext
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