NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

The molecular basis underlying glioblastoma (GBM) heterogeneity and plasticity is not fully understood. Using transcriptomic data of human patient-derived brain tumor stem cell lines (BTSCs), classified based on GBM-intrinsic signatures, we identify the AP-1 transcription factor FOSL1 as a key regul...

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Veröffentlicht in:	eLife Jg. 10
Hauptverfasser:	Marques, Carolina, Unterkircher, Thomas, Kroon, Paula, Oldrini, Barbara, Izzo, Annalisa, Dramaretska, Yuliia, Ferrarese, Roberto, Kling, Eva, Schnell, Oliver, Nelander, Sven, Wagner, Erwin F, Bakiri, Latifa, Gargiulo, Gaetano, Carro, Maria Stella, Squatrito, Massimo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England eLife Sciences Publications Ltd 17.08.2021 eLife Sciences Publications, Ltd
Schlagworte:	Activator protein 1 Brain cancer Brain Neoplasms - genetics Brain stem Brain tumors Cancer Biology Cell cycle Cell Line, Tumor Classification Datasets FOSL1 FRA-1 GBM Gene expression Gene Expression Regulation, Neoplastic Glioblastoma Glioblastoma - genetics Humans MAP kinase mesenchymal Mesenchyme Mutants Mutation Neoplastic Stem Cells - pathology Neural stem cells Neurofibromatosis Neurofibromin 1 Neurofibromin 1 - genetics Neurofibromin 1 - metabolism NF1 Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-fos - metabolism Stem cell transplantation Stem cells Transcription factors Transcriptomics Tumor cell lines Tumors FOSL1 mouse GBM mesenchymal NF1 FRA-1 cancer biology human
ISSN:	2050-084X, 2050-084X
Online-Zugang:	Volltext
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