Estimating individualized treatment rules with risk constraint

Individualized treatment rules (ITRs) recommend treatments based on patient‐specific characteristics in order to maximize the expected clinical outcome. At the same time, the risks caused by various adverse events cannot be ignored. In this paper, we propose a method to estimate an optimal ITR that...

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Bibliographic Details
Published in:	Biometrics Vol. 76; no. 4; pp. 1310 - 1318
Main Authors:	Huang, Xinyang, Xu, Jin
Format:	Journal Article
Language:	English
Published:	United States Blackwell Publishing Ltd 01.12.2020
Subjects:	Algorithms Constraints DC programming individualized treatment rule multi‐category classification Optimization outcome weighted learning personalized medicine risk risk constraint Risk management system optimization DC programming risk constraint outcome weighted learning multi-category classification individualized treatment rule personalized medicine
ISSN:	0006-341X, 1541-0420, 1541-0420
Online Access:	Get full text
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